Entrainment of human circadian rhythms by physical exercise : analysis with desynchrony protocol

本研究旨在阐明强光和体育锻炼对人体昼夜节律影响的时间线索的差异，体育锻炼效果的机制以及锻炼效果与强度的关系(2005)：15名男性受试者被分为体育锻炼组和非锻炼组，在不知道一天的时间的情况下，在弱光照的隔离设施中停留7d。实验第3~6天，运动组用自行车测功器进行体育锻炼，每天2小时。结果显示，两组大鼠血浆褪黑素节律均呈延迟相移，两组间褪黑激素节律参数无明显差异。本实验中的运动时间被认为是在运动昼夜节律的预期相位响应曲线的死区内进行的。(2006年)：7-8男性亚…更多的受试者参加了两个实验，体育锻炼和非锻炼。在主观晚上用自行车测功器进行体育锻炼。结果，在非运动实验中，血浆褪黑激素节律显示出延迟相移，而在运动实验中，褪黑激素节律没有改变。另一方面，7-8岁男性受试者的日常生活日程表在暗淡光照的隔离设施中被提前8h，并固定4d。同时，受试者每天进行4小时的体育锻炼。之后，他们被释放到自由奔跑的条件下，睡觉和起床的时间由受试者决定。结果表明，运动对血浆褪黑素节律的影响不大，但运动使睡眠-觉醒节律明显提前。综上所述，这些发现表明，体育锻炼是人类睡眠-醒来周期的潜在时间线索，但不是昼夜节律的潜在时间线索。较少

The purpose of the present study is to elucidate the difference in the effect on the human circadian rhythms between bight light and physical exercise as time cues, the mechanism of the effect of physical exercise and the relation between the effect and strength of exercise(2005) : 15 male subjects were divided into two groups; physical exercise and non-exercise, and stayed in an isolation facilities with illumination of low light intensity for 7 day without knowing the time of day. From the third to 6th of experimental day, the subjects in the exercise group performed physical exercise with a bicycle erometer for 2 hours per day. As a result, the plasma melatonin rhythm showed phase-delay shifts in both groups, and there was no difference in the parameter of melatonin rhythm between two groups. The timing of physical exercise in this experiment was regarded as scheduled in the dead zone of an expected phase response curve of circadian rhythm for physical exercise.(2006) : 7-8 male sub … More jects participated in two experiments, physical exercise and non-exercise. Physical exercise with bicycle ergometer was performed in the subjective evening. As a result, the plasma melatonin rhythm showed phase-delay shifts in a non-exercise experiment, while the melatonin rhythm was not shifted in an exercise experiment. On the other hand, the routine life schedule of 7-8 male subjected was phase-advanced by 8 h in an isolation facility with dim illumination and fixed for 4 days. Meanwhile, the subjects performed physical exercise for 4 hours per day. After that, they were released into free-running conditions where the times of going to bed and get up were decided by the subjects. As a results, the plasma melatonin rhythm was not affected by the phase-advance shift of life schedule, but the sleep-wake rhythm was significantly phase-advanced by physical exercise. Together all, these findings indicate that physical exercise is a potential time cue for the human sleep-wake cycles but not for the circadian rhythms. Less