Research on the reevaluation of effectiveness in recipients of influenza vaccines

流感疫苗接种者有效性再评价研究

• 批准号: 17590570
• 负责人: TAKAHASHI Kazuo
• 金额: $ 2.24万
• 依托单位: Osaka Prefectural Institute of Public Health
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17590570/
• 关键词: influenza; vaccine; neutralization; hemagglutination

In a pediatric clinic at K city in Osaka prefecture, 156 children aged 1-5 year old received 2 doses of an influenza vaccine, and of them 53 recipients were enrolled in this study. Of 53 vaccinees, 21 children suffered from influenza diagnosed by rapid test. Of 21 patients A or B type influenza viruses were isolated from 5 patients, respectively. Hemagglutination inhibition assay and microneutralisation assay of acute phase sera were performed against both vaccine strains and autologous viruses which were isolated from the patients. To vaccine strains all patients showed positive HI and NT and 9 out of 10 patients were over 40 HI and 8 out of 10 patients showed NT over 40, 2 were NT 20. On the contrary, to the autologous virus 4 patients showed HI titer over 40 and 4 patients were below 10. Only one patient showed NT titer of 20, and the others were below 10. These findings suggest that in the vaccinees the suffering from influenza would be more associated with NT titer rather than HI titer.

在大阪府K市的一家儿科诊所，156名1-5岁儿童接种了2剂流感疫苗，其中53名接受者参加了这项研究。 53名疫苗接种者中，经快速检测确诊有21名儿童患有流感。在21名患者中，分别从5名患者中分离出A型或B型流感病毒。针对从患者中分离的疫苗株和自体病毒进行了血凝抑制测定和急性期血清的微量中和测定。对于疫苗株，所有患者的HI和NT均呈阳性，10名患者中有9名HI超过40，10名患者中有8名NT超过40，2名NT 20。相反，对于自体病毒，4名患者的HI滴度超过40，4名患者的滴度低于10。只有一名患者的NT滴度为20，其他患者均低于10。这些结果表明，接种者中患有流感与 NT 滴度而非 HI 更相关 效价。

项目成果

A型、B型の鑑別が可能なインフルエンザ迅速診断キット改良型「ポクテムインフルエンザA/B」の評価

可区分A型和B型的改良型流感快速诊断试剂盒“Poctem Influenza A/B”的评价

• 发表时间: 2005
• 期刊: Sysmex Journal 28
• 作者: 高橋和郎;他
• 通讯作者: 他

Research on the reevaluation of effectiveness in recipients of influenza vaccines

流感疫苗接种者有效性再评价研究

• 发表时间: 2007
• 期刊: Saishinigaku(Pandemic influenza preparedness) 62;(2)
• 作者: Kobayashi K;Yamamoto K;Tsuboi H;Tatsumi A;Akamatsu Y;Hori R;Watanabe M.;Kazuo Takahashi
• 通讯作者: Kazuo Takahashi