心・血管の構築変化と心不全の発現を規定する適応限界点に関する研究

决定心脏和血管结构变化以及心力衰竭发作的适应性断裂点的研究

• 批准号: 06213209
• 负责人: 友池 仁暢
• 金额: $ 1.22万
• 依托单位: Yamagata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06213209/
• 关键词: 心筋肥大; 心室拡大; 動静脈短絡; 心ポンプ機能; β受容体

心臓の肥大・拡張モデルの確立と心機能評価(1)家兎の頚部動脈と静脈間に側々吻合路を作製し、容量負荷心を作製した。短絡血流量を安静時頚動脈血流量の4倍に設定したところ、慢性期に著明な心臓の拡大と心筋の肥大を観察することができた。すなわち、動静脈短絡を作製して12週目に心臓の形態計測を行ったところ、Sham手術例に比較して右室は65%,左室は66%の重量増加と心内容積の増大を認めた。心機能の変化については、カテ先血圧形を用いて左室の内圧を測定し、dp/dtを心収縮能の指標とした。短絡路形成による容量負荷12週において,Ca^<2+>やβ受容体刺激に対する反応性の低下を認めた。すなわち、心肥大の過程においてβ受容体のdown regulationが示唆された。Ca^<2+>感受性の低下が何時生じたかを明らかにする為経時的検討を行った。(2)右室の圧負荷モデルについてはモノクロタリンの腹腔内注射によって作製することができた。TxA_2受容体拮抗剤に対する反応からモノクロタリン注入初期における血小板凝集亢進が病態の形成に関与していたものと思われた。(3)右室と左室の相互干渉に関する検討β受容体刺激とCa^<2+>拮抗剤の右心室機能と左心室機能に及ぼす効果を検討した。

The heart is enlarged and the heart is in good condition. (1) the movement and quiet room of the home, the car, the heart, the heart. When the blood flow is short and quiet, the blood flow is 4 times higher than that of the rest. In the chronic phase, the heart is obviously enlarged, the heart is enlarged, the heart is hypertrophic, and the symptoms are observed. The weight of the right ventricle was 65% higher than that of the right ventricle, and the weight of the left ventricle was 66% higher than that of the right ventricle. The weight of the left ventricle was 66% higher than that of the right ventricle. The heart function was measured by left ventricular echocardiography, and the heart function was measured by dp/dt heart function. The short circuit results in a capacitive capacity of 12%, and Ca ^ & lt;2+> β is stimulated by a capacitor that reverses sexual depression. The process of hypertrophy and cardiac hypertrophy is characterized by the presence of β-receptacle and down regulation. CA ^ & lt;2+> has low sensitivity. When does it give birth to a diagnosis? when does it show that it is normal? (2) in the right ventricle, the abdominal cavity was injected intraperitoneally. The TxA_2 receptor antagonized the growth of platelet aggregation in the early stage of injection, increased platelet agglutination, pathomorphology and pathological changes in the early stage of injection. (3) Ca ^ & lt;2+> antagonized the right ventricular motor function and left ventricular motor function.

项目成果

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