Study on risk assessment of subclinical neurobehavioral effects of environmental factors

环境因素亚临床神经行为影响的风险评估研究

• 批准号: 14570325
• 负责人: YOKOYAMA Kazuhito
• 金额: $ 2.18万
• 依托单位: Mie University (2003)The University of Tokyo (2002)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570325/
• 关键词: Chemical substances; Subclinical effects; Neurobebavioral effects; Risk assessment; Risk management; Epidemiology; 神経行動障害; 非顕性影響; リスクマネージメント

Risk assessment is a process to avoid, reduce or manage the risk. In environmental health, risk assessment is conducted as quantification of incidence of the events which are harmful to health of target populations. Indices used for risk assessment include mortality or mortality rate, loss of life expectancy etc, which are called end-point. The present study was aimed at establishing a method for the risk assessment of subclinical neurobehavioral effects of environmental factors. For this purpose, literatures on the effects of chemicals such as lead, solvents, etc were collected and carefully reviewed. Also, dose-effect (response) relationships of various chemicals were examined through field studies among human populations. The results have been presented at scientific meetings as well as international scientific journals. By this effort, exposure limit of occupational exposure to acrylamide by Japan Society of Industrial Health has been amended.

风险评估是一个避免、减少或管理风险的过程。在环境健康方面，风险评估是对危害目标人群健康的事件的发生率进行量化。用于风险评估的指标包括死亡率或死亡率、预期寿命损失等，称为终点。本研究旨在建立环境因素亚临床神经行为效应的风险评估方法。为此，收集了关于铅、溶剂等化学物质的影响的文献，并进行了仔细的审查。此外，通过在人群中进行实地研究，研究了各种化学品的剂量-效应(反应)关系。研究结果已在科学会议和国际科学期刊上发表。通过这一努力，日本工业卫生学会对丙烯酰胺职业暴露限值进行了修订。

项目成果

横山和仁: "鉛中毒-最近のレビューより"産業医学ジャーナル. 25. 86-90 (2002)

Kazuhito Yokoyama：“铅中毒 - 来自最近的评论”工业医学杂志 25. 86-90 (2002)。

Onuki, M.: "Assessment of urinary cotinine as a marker of nicotine absorption from tobacco leaves"Journal of Occupational Health. 45(印刷中). (2003)

Onuki, M.：“作为烟叶尼古丁吸收标志物的尿可替宁评估”《职业健康杂志》45（出版中）。

Yokoyama, K: "Subclinical cerebellar anterior lobe, vestibule-cerebellar and spinocerebellar afferent effects in young female lead workers in China: computerized posturography with sway frequency analysis and brainstem auditory evoked potentials."Industri

Yokoyama, K：“中国年轻女性领导工人的亚临床小脑前叶、前庭小脑和脊髓小脑传入效应：具有摇摆频率分析和脑干听觉诱发电位的计算机姿势描记法。”

Vigeh, M.: "Increased blood lead in gestational hypertension : A study on women without occupational lead exposure in Teheran Iran"The 17th Asian Conference on Occupational Health, Taipei, Taiwan. (2002)

Vigeh, M.：“妊娠高血压中血铅增加：对伊朗德黑兰没有职业铅暴露的妇女的研究”，第 17 届亚洲职业健康会议，台湾台北。

Onuki, M: "Assessment of urinary cotinine as a marker of nicotine absorption from tobacco leaves : a study on tobacco farmers in Malaysia."Journal of Occupational Health. 45. 140-145 (2003)

Onuki, M：“尿可替宁评估作为烟叶尼古丁吸收的标志：对马来西亚烟农的一项研究。”职业健康杂志。