Individual susceptibility to chemical substances

为明确与个体敏感性差异有关的基因簇，对病房开发楼的受试者和接触化学物质的工人进行了调查。调查项目为神经生理和行为改变以及遗传毒性效应(微核试验)。本研究纳入分析对象的基因簇包括与化学物质代谢相关的细胞色素P-450亚家族基因，以及参与化学物质损伤DNA修复的DNA修复基因。旨在构建能够综合判断化学品效应敏感性个体差异的监测体系。也就是说，充分利用数理统计程序，综合分析了基因多型因子与暴露指数的变化(个体敏感性差异)或神经毒性和遗传毒性影响指数的关系。报告是在科学会议上完成的，同时向国际期刊提交了原始论文。以上结果是对结果报告(小册子对象)的总结。

Subjects in the development building of sick house, and workers with chemical exposures were surveyed for the purpose of clarifying the gene cluster relevant to the individual differences of the sensibility. Investigation items were neurophysiological and behavioral changes as well as genotoxicitic effects (micro nuclei test). The gene clusters made into the object of analysis by this research were those belonging to the sub family of the cytochrome P-450 in connection with chemicals metabolism, and a DNA repair genes which participates in restoration of DNA damaged by chemicals exposure. This aimed at construction of the monitoring system which can judge synthetically the individual differences of the sensibility about effects of chemicals. That is, it was analyzed synthetically how a gene pleiotype factor would be concerned with change (individual differences of sensibility) of an exposure index, or a neurotoxicity and a genetic toxicity influence index, making full use of the mathematical statistics-procedure. Report were performed at scientific meetings, while creating the original paper to the international journals. The above results were summarized for the result report (booklet object).