Individual susceptibility to chemical substances

个体对化学物质的敏感性

• 批准号: 16390181
• 负责人: YOKOYAMA Kazuhito
• 金额: $ 9.6万
• 依托单位: Mie University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16390181/
• 关键词: Chemical substance; Health effects; Neuro behavioral medicine; Neuro physiology; Micro nuclei test; DNA addict; Polymor phism; P450; NA付加体

Subjects in the development building of sick house, and workers with chemical exposures were surveyed for the purpose of clarifying the gene cluster relevant to the individual differences of the sensibility. Investigation items were neurophysiological and behavioral changes as well as genotoxicitic effects (micro nuclei test). The gene clusters made into the object of analysis by this research were those belonging to the sub family of the cytochrome P-450 in connection with chemicals metabolism, and a DNA repair genes which participates in restoration of DNA damaged by chemicals exposure. This aimed at construction of the monitoring system which can judge synthetically the individual differences of the sensibility about effects of chemicals. That is, it was analyzed synthetically how a gene pleiotype factor would be concerned with change (individual differences of sensibility) of an exposure index, or a neurotoxicity and a genetic toxicity influence index, making full use of the mathematical statistics-procedure. Report were performed at scientific meetings, while creating the original paper to the international journals. The above results were summarized for the result report (booklet object).

为明确与易感性个体差异相关的基因簇，对病室建设中的受试者和化学品接触工人进行了调查。研究项目包括神经生理学和行为学改变以及遗传毒性效应（微核试验）。本研究分析的基因簇是属于与化学物质代谢有关的细胞色素P-450亚家族的基因簇，以及参与化学物质暴露损伤的DNA修复的DNA修复基因。目的是建立一个能综合判断个体对化学品效应敏感性差异的监测系统。也就是说，它是综合分析基因的多型因素将如何与暴露指数的变化（敏感性的个体差异），或神经毒性和遗传毒性影响指数，充分利用数学代数程序。在科学会议上进行报告，同时为国际期刊撰写原始论文。总结上述结果用于结果报告（小册子对象）。

项目成果

Effects of urbanization, economic development, and migration of workers on suicide mortality in Japan

• DOI: 10.1016/s0277-9536(03)00285-5
• 发表时间: 2004-03-01
• 期刊: SOCIAL SCIENCE & MEDICINE
• 影响因子: 5.4
• 作者: Otsu, A;Araki, S;Voorhees, AS
• 通讯作者: Voorhees, AS

Effects of static load on the weight and protein content in the muscles of the mouse : a simulation of prolonged standing in the workplace

静负荷对小鼠体重和肌肉蛋白质含量的影响：模拟在工作场所长时间站立

• 发表时间: 2004
• 期刊: Industrial Health 42
• 作者: Ueno;S.
• 通讯作者: S.

Evidence of association of the CYP2E1 genetic polymorphism with micronuclei frequency in human peripheral blood.

• DOI: 10.1016/j.mrfmmm.2003.10.007
• 发表时间: 2004-02
• 期刊: Mutation research
• 作者: H. Ishikawa;Hidetaka Yamamoto;Ying Tian;M. Kawano;T. Yamauchi;K. Yokoyama

Relationship between fetal weight, placental growth and litter size in mice from mid- to late-gestation

• DOI: 10.1016/j.reprotox.2005.08.002
• 发表时间: 2006-04-01
• 期刊: REPRODUCTIVE TOXICOLOGY
• 影响因子: 3.3
• 作者: Ishikawa, H;Seki, R;Yokoyama, K
• 通讯作者: Yokoyama, K

A polymorphism of the methionine synthase reductase gene increases chromosomal damage in peripheral lymphocytes in smokers.

• DOI: 10.1016/j.mrfmmm.2006.02.004
• 发表时间: 2006-07
• 期刊: Mutation research
• 作者: H. Ishikawa;Takashi Ishikawa;Yu Miyatsu;Kazuo Kurihara;A. Fukao;K. Yokoyama