Individual susceptibility to chemical substances

对疗养院开发楼工作人员和接触化学品的工人进行了调查，目的是澄清与敏感性个体差异相关的基因簇。调查项目为神经生理和行为改变以及基因毒性效应（微核试验）。本研究分析的基因簇是与化学物质代谢有关的细胞色素P-450亚家族的基因簇，以及参与化学物质暴露损伤DNA修复的DNA修复基因簇。旨在建立能够综合判断化学品效应敏感性个体差异的监测系统。即充分运用数理统计方法，综合分析基因多型因子与暴露指数、神经毒性和遗传毒性影响指数的变化（敏感性个体差异）之间的关系。报告是在科学会议上进行的，同时将原创论文提交给国际期刊。将以上结果总结为结果报告（小册子对象）。

Subjects in the development building of sick house, and workers with chemical exposures were surveyed for the purpose of clarifying the gene cluster relevant to the individual differences of the sensibility. Investigation items were neurophysiological and behavioral changes as well as genotoxicitic effects (micro nuclei test). The gene clusters made into the object of analysis by this research were those belonging to the sub family of the cytochrome P-450 in connection with chemicals metabolism, and a DNA repair genes which participates in restoration of DNA damaged by chemicals exposure. This aimed at construction of the monitoring system which can judge synthetically the individual differences of the sensibility about effects of chemicals. That is, it was analyzed synthetically how a gene pleiotype factor would be concerned with change (individual differences of sensibility) of an exposure index, or a neurotoxicity and a genetic toxicity influence index, making full use of the mathematical statistics-procedure. Report were performed at scientific meetings, while creating the original paper to the international journals. The above results were summarized for the result report (booklet object).