International collaboration study on health effects and safety use of pesticides.

关于农药健康影响和安全使用的国际合作研究。

• 批准号: 13576019
• 负责人: YOKOYAMA Kazuhito
• 金额: $ 3.46万
• 依托单位: Mie University (2003)The University of Tokyo (2001-2002)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13576019/
• 关键词: Pesticide; Health effects; Malaysia; Tobacco growing; Nervous system function; Epidemiology; Nicotine poisoning; Green tobacco sickness; 健康被害; 国際情報交換; 国際保健; 神経生理学的検査

Few epidemiological studies have been conducted on the effects of pesticides on neurobehavioral function in human populations. The present study was aimed at elucidating (1) subclinical neurobehavioral effects of pesticides, (2) relationships between these effects and safety use, and (3) factors influencing safety behavior among tobacco farmers in Kelatntan, Malaysia. The study was carried out under the collaboration with Professor Rusli Bin Nordin, Universiti Sains Malaysia. Surveys using neurobehavioral and neurolectrophysiological tests and questionnaires were conducted together with biological monitoring of exposures, i.e. analyses of pesticides and their metabolites in serum and urine as well as measurement of serum cholinesterase activities. Furthermore, effects of nicotine absorbed from green tobacco leaves were examined. It was observed that pesticide absorption caused neuroelectrophysiological effects and subjective symptoms, which were related to safety behaviors such as use of personal protective equipments. Green Tobacco Sickness due to nicotine absorption was also demonstrated in the farmers.

关于农药对人群神经行为功能影响的流行病学研究很少。本研究旨在阐明(1)农药的亚临床神经行为效应，(2)这些效应与安全使用的关系，以及(3)影响马来西亚吉拉丹岛烟农安全行为的因素。这项研究是与马来西亚圣斯大学的Rusli Bin Nordin教授合作进行的。利用神经行为学和神经电生理学测试和问卷进行调查，同时对接触情况进行生物监测，即分析血清和尿液中的农药及其代谢物，以及测量血清胆碱酯酶活性。此外，还考察了绿烟叶对尼古丁的吸收效应。观察到农药吸收引起的神经电生理效应和主观症状与使用个人防护装备等安全行为有关。烟农因吸收尼古丁而出现绿烟病。

项目成果

Hotta, Y.: "Social life factors for the mortality from non-motor-vehicle accident"Japanese Journal of Occpational Medicine and Traumatology. 49. 156-163 (2001)

Hotta，Y.：“非机动车辆事故死亡率的社会生活因素”日本职业医学和创伤学杂志。

横山和仁: "鉛中毒-最近のレビューより"産業医学ジャーナル. 25. 86-90 (2002)

Kazuhito Yokoyama：“铅中毒 - 来自最近的评论”工业医学杂志 25. 86-90 (2002)。

荒記俊一: "中毒学"朝倉書店. 399 (2002)

荒木俊一：《成瘾学》朝仓书店 399 (2002)。

Yokoyama, K.: "Subclinical cerebellar anterior lobe, vestibule-cerebellar and spinocerebellar afferente effects in young female lead workers in China : computerized posturography with sway frequency analysis and brainstem auditory evoked potentials."Indus

Yokoyama, K.：“中国年轻女性领导工人的亚临床小脑前叶、前庭小脑和脊髓小脑传入效应：具有摇摆频率分析和脑干听觉诱发电位的计算机姿势描记法。”

Ueno, S.: "Effects of pH and temperature on force and stiffness of skeletal muscle fibers during contraction and relaxation in relation to musculoskeletal disorders."Industrial Health. 40. 362-369 (2002)

Ueno, S.：“pH 值和温度对与肌肉骨骼疾病相关的收缩和松弛过程中骨骼肌纤维的力和刚度的影响。”工业健康。