International collaboration study on health effects and safety use of pesticides.

关于农药对人群神经行为功能影响的流行病学研究很少。本研究旨在阐明(1)农药的亚临床神经行为效应，(2)这些效应与安全使用的关系，以及(3)影响马来西亚吉拉丹岛烟农安全行为的因素。这项研究是与马来西亚圣斯大学的Rusli Bin Nordin教授合作进行的。利用神经行为学和神经电生理学测试和问卷进行调查，同时对接触情况进行生物监测，即分析血清和尿液中的农药及其代谢物，以及测量血清胆碱酯酶活性。此外，还考察了绿烟叶对尼古丁的吸收效应。观察到农药吸收引起的神经电生理效应和主观症状与使用个人防护装备等安全行为有关。烟农因吸收尼古丁而出现绿烟病。

Few epidemiological studies have been conducted on the effects of pesticides on neurobehavioral function in human populations. The present study was aimed at elucidating (1) subclinical neurobehavioral effects of pesticides, (2) relationships between these effects and safety use, and (3) factors influencing safety behavior among tobacco farmers in Kelatntan, Malaysia. The study was carried out under the collaboration with Professor Rusli Bin Nordin, Universiti Sains Malaysia. Surveys using neurobehavioral and neurolectrophysiological tests and questionnaires were conducted together with biological monitoring of exposures, i.e. analyses of pesticides and their metabolites in serum and urine as well as measurement of serum cholinesterase activities. Furthermore, effects of nicotine absorbed from green tobacco leaves were examined. It was observed that pesticide absorption caused neuroelectrophysiological effects and subjective symptoms, which were related to safety behaviors such as use of personal protective equipments. Green Tobacco Sickness due to nicotine absorption was also demonstrated in the farmers.