Establishment of a new non-invasive measurement for in vivo glucose metabolism and estrogen receptorexpression of breast cancer

1.本项目旨在通过无创检测体内葡萄糖代谢和雌激素受体浓度，建立一种新的乳腺癌诊断方法。本文利用几个充满正电子发射体的幽灵体，对具有符合检测系统的闪烁相机重合相机的基本性能进行了测试。计数率性能与放射性浓度关系良好，但在低活度区域受到限制。因此，临床研究应在注射185MBq后120分钟进行。灵敏度和空间分辨率均较好。球影研究表明，当病灶周围存在放射性本底时，无法检测到直径小于20mm的病灶。我们考察了重合相机的临床表现。我们用2-脱氧2-[^<18>F]氟-d -葡萄糖（F-18 FDG）和重合照相机测量了74例恶性肿瘤患者体内葡萄糖代谢。将结果与专用PET相机进行比较，符合相机的灵敏度为83.5%。重合相机经常遗漏小病变（小于10mm）和位于深部的病变。我们用专用PET相机检测了16α-[^<18 b> F]氟-17β-雌二醇（F-18 FES）在4名健康成年男性志愿者体内的分布和动力学。活性最高的是肝脏。注射185MBq F-18 FES后，肝脏堆积迅速增加，10分钟后达到平稳期。在肺、脾、肌肉和骨髓的积累相对较少。注射后60分钟开始全身扫描。F-18 FES在肝脏、胆道、肾脏、泌尿道等排泄器官均有高蓄积。

1.The aim of this project is to establish a new diagnostic method for breast cancer by measuring the in vivo glucose metabolism and the estrogen receptor concentration non-invasively.2.We examined the basic performance of coincidence camera, which is a scintillation camera with coincidence detecting system, by using several phantoms filled with positron emitter. Good relationship between the count rate performance and radioactivity concentration was observed, while it was limited in low activity area. Thus the clinical studies should be performed at 120 minutes after injection of 185MBq. The sensitivity and spatial resolution were satisfactory good. The ball phantom study showed that the lesions with 20mm or less of diameter could not be detected when radioactive background existed around the lesions.3.We examined the clinical performance of coincidence camera. We measured in vivo glucose metabolism in 74 patients with malignant tumors by 2-deoxy2-[^<18>F]fluoro-D- glucose (F-18 FDG) and coincidence camera. When we compared the results with that of dedicated PET camera, the sensitivity of coincidence camera was 83.5%. The coincidence camera often missed small lesions (less than 10mm) and those located in deep regions.4.We examined the distribution and kinetics of 16α-[^<18>F]fluoro-17β-estradiol (F-18 FES) in 4 healthy adult male volunteers by dedicated PET camera. Highest activity was observed in the liver. After 185MBq of F-18 FES injection, the hepatic accumulation rapidly increased and reached a plateau at 10 minutes. Accumulation in the lung, spleen, muscle and bone marrow was relatively low. Whole body scans were started at 60 minutes after injection. High F-18 FES accumulation was observed in excretory organs of liver, biliary system, kidney and urinary tract.