Establishment of a new non-invasive measurement for in vivo glucose metabolism and estrogen receptorexpression of breast cancer

建立乳腺癌体内葡萄糖代谢和雌激素受体表达的新非侵入性测量方法

• 批准号: 14570867
• 负责人: SASAKI Masayuki
• 金额: $ 2.24万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570867/
• 关键词: F-18 estradiol; F-18 FDG; PET; coincidence camera; estrogen receptor; glucose metabolism; ポジトロンCT; F-18エストラジオール

1.The aim of this project is to establish a new diagnostic method for breast cancer by measuring the in vivo glucose metabolism and the estrogen receptor concentration non-invasively.2.We examined the basic performance of coincidence camera, which is a scintillation camera with coincidence detecting system, by using several phantoms filled with positron emitter. Good relationship between the count rate performance and radioactivity concentration was observed, while it was limited in low activity area. Thus the clinical studies should be performed at 120 minutes after injection of 185MBq. The sensitivity and spatial resolution were satisfactory good. The ball phantom study showed that the lesions with 20mm or less of diameter could not be detected when radioactive background existed around the lesions.3.We examined the clinical performance of coincidence camera. We measured in vivo glucose metabolism in 74 patients with malignant tumors by 2-deoxy2-[^<18>F]fluoro-D- glucose (F-18 FDG) and coincidence camera. When we compared the results with that of dedicated PET camera, the sensitivity of coincidence camera was 83.5%. The coincidence camera often missed small lesions (less than 10mm) and those located in deep regions.4.We examined the distribution and kinetics of 16α-[^<18>F]fluoro-17β-estradiol (F-18 FES) in 4 healthy adult male volunteers by dedicated PET camera. Highest activity was observed in the liver. After 185MBq of F-18 FES injection, the hepatic accumulation rapidly increased and reached a plateau at 10 minutes. Accumulation in the lung, spleen, muscle and bone marrow was relatively low. Whole body scans were started at 60 minutes after injection. High F-18 FES accumulation was observed in excretory organs of liver, biliary system, kidney and urinary tract.

1.该项目的目的是通过无创地测量体内葡萄糖代谢和雌激素受体浓度来建立一种新的乳腺癌诊断方法。2.我们通过使用几个充满正电子发射器的体模检查了符合相机的基本性能，这是一种具有符合检测系统的闪烁相机。计数率性能与放射性浓度之间观察到良好的关系，但在低活性区域有限。因此，临床研究应在注射185MBq后120分钟进行。灵敏度和空间分辨率令人满意。球体模型研究表明，当病灶周围存在放射性背景时，直径20mm以下的病灶无法被检测到。3.检查符合相机的临床性能。我们通过2-脱氧2-[^ 18 F]氟-D-葡萄糖(F-18 FDG)和符合相机测量了74名恶性肿瘤患者的体内葡萄糖代谢。当我们将结果与专用 PET 相机的结果进行比较时，符合相机的灵敏度为 83.5%。重合相机常常会漏掉小病灶（小于10mm）和位于深层区域的病灶。4.我们通过专用PET相机检查了4名健康成年男性志愿者中16α-[^<18>F]氟-17β-雌二醇（F-18 FES）的分布和动力学。在肝脏中观察到最高活性。注射 185MBq F-18 FES 后，肝脏蓄积迅速增加，并在 10 分钟时达到平台。在肺、脾、肌肉和骨髓中的积累相对较低。注射后 60 分钟开始全身扫描。在肝脏、胆道系统、肾脏和泌尿道的排泄器官中观察到高F-18 FES积累。

项目成果

Lesion detectability of a gamma camera based coincidence system with FDG in patients with malignant tumors : a comparison with dedicated positron emission tomography.

基于伽玛相机的符合系统与 FDG 在恶性肿瘤患者中的病变检测能力：与专用正电子发射断层扫描的比较。

• 发表时间: 2004
• 期刊: Annals of Nuclear Medicine 18・2
• 作者: Hirofumi Koga;et al.
• 通讯作者: et al.