DIAGNOSIS AND AN EVALUATION OF THERAPEUTIC RESPONSE OF THYROID CANCER BY ASSESSING TUMOR METABOLISM USING PET.

通过使用 PET 评估肿瘤代谢来诊断甲状腺癌并评估治疗效果。

• 批准号: 07671011
• 负责人: SASAKI Masayuki
• 金额: $ 1.41万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07671011/
• 关键词: Positron emission tomography (PET); F-18-FDG; C-11-methionine; Thyroid cancer

1.We measured both a glucose metabolism and an amino acid metabolism of the normal thyroid gland in healthy volunteers by using positron emission tomography (PET) with F-18-fluorodeoxyglucose (FDG) and C-11-methionine (MET), respectively. The FDG uptake of the normal thyroid gland was 0.97(]SY.+-。[)0.20 SUV (n=5), and the MET uptake of that was 1.02(]SY.+-。[)0.29 SUV (n=3).2.In newly diagnosed patients with thyroid tumor, the FDG uptake of papillary carcinoma was 6.68 SUV (n=2) and that of follicular adenoma 2.12(]SY.+-。[)0.36 SUV (n=3).The MET uptake of papillary carcinoma was 3.40 SUV (n=2) and 3.8(]SY.+-。[)0.70 SUV (n=3). Thus, both the glucose metabolism and the amino acid metabolism of thyroid tumor were increased in comparison with those of the normal thyroid gland.3.In patients with recurrent tumor after the resection, the FDG uptake of papillary carcinoma was 4.40(]SY.+-。[)3.04 SUV (n=14) and that of follicular carcinoma 4.62 SUV (n=2). The MET uptake of papillary carcinoma was 2.90 SUV (n=1) and 7.80 SUV (n=1). Thus, both the glucose metabolism and the amino acid metabolism of recurrent thyroid carcinoma were increased in comparison with those of the normal thyroid gland.4.We compared the FDG-PET and I-131scintigraphy for the detection of thyroid cancer in 10 patients consisting of 4 with recurrent carcinoma and 6 without. The sensitivity, specificity and accuracy of the FDG-PET was 100%, 100% and 100%, respectively, while those of the I-131 scintigraphy 50%, 0% and 30%, respectively.5.In conclusion, both the FDG-PET for measuring a glucose metabolism and the MET-PET for measuring an amino acid metabolism were useful for the differential diagnosis of thyroid tumors. Furthermore, the FDG-PET was superior to the I-131 scintigraphy for the detection of the recurrent thyroid cancer.

1.采用正电子发射断层扫描(PET)技术，对健康志愿者正常甲状腺的葡萄糖代谢和氨基酸代谢进行了研究。正常甲状腺的FDG摄取率为0.97(Sy.+-)。[]0.20SUV(n=5)，MET摄取为1.02(]sy.+-)。2.新诊断的甲状腺肿瘤中，乳头状癌摄取FDG为6.68 SUV(n=2)，滤泡性腺瘤摄取FDG为2.12(SY+-)。乳头状癌的MET摄取率分别为3.40SUV(n=2)和3.8SUV(n=-)。[]0.70SUV(n=3)。因此，甲状腺肿瘤的葡萄糖代谢和氨基酸代谢均高于正常甲状腺。3.在肿瘤切除后复发的患者中，乳头状癌的FDG摄取率为4.40(SY.+-)。[]3.04 SUV(n=14)，滤泡性癌4.62 SUV(n=2)。乳头状癌的MET摄取分别为2.90SUV(n=1)和7.80SUV(n=1)。因此，复发甲状腺癌的葡萄糖代谢和氨基酸代谢均高于正常甲状腺。4.比较FDG-PET和I-131对10例甲状腺癌的诊断价值，其中4例复发甲状腺癌，6例未复发。FDG-PET的敏感性、特异性和准确性分别为100%、100%和100%，I-131核素显像的敏感性、特异性和准确性分别为50%、0%和30%。5.总之，FDG-PET和MET-PET对甲状腺肿瘤的鉴别诊断均有价值。此外，FDG-PET在检测复发甲状腺癌方面优于I-131核素显像。

项目成果

Masayuki Sasaki, Yuichi Ichiya, Yasuo Kuwabara, Yuko Akashi, Tsuyoshi Yoshida, Toshimitsu Fukumura and Kouji Masuda.: "An evaluation of FDG-PET in the detection and differentiation of thyroid tumors." Nuclear Medicine Communications. 18. 957-963 (1997)

Masayuki Sasaki、Yuichi Ichiya、Yasuo Kuwabara、Yuko Akashi、Tsuyoshi Yoshida、Toshimitsu Fukumura 和 Kouji Masuda.：“FDG-PET 在甲状腺肿瘤检测和分化中的评估。”

Masayuki Sasaki, et al: "An evaluation of FDG-PET in the detection and differentiation of thyroid tumors" Nuclear Medicine Communications. 18. 957-963 (1997)

Masayuki Sasaki 等人：“FDG-PET 在甲状腺肿瘤检测和分化中的评估”《核医学通讯》。