DIAGNOSIS AND AN EVALUATION OF THERAPEUTIC RESPONSE OF THYROID CANCER BY ASSESSING TUMOR METABOLISM USING PET.

1.我们用正电子发射断层扫描（PET）分别用f -18-氟脱氧葡萄糖（FDG）和c -11-蛋氨酸（MET）测量了健康志愿者正常甲状腺的葡萄糖代谢和氨基酸代谢。正常甲状腺对FDG的摄取为0.97(]SY.+- - [)0.20 SUV (n=5)，对MET的摄取为1.02(]SY.+- [)0.29 SUV (n=3).2。在新诊断的甲状腺肿瘤患者中，乳头状癌的FDG摄取为6.68 SUV (n=2)，滤泡腺瘤的FDG摄取为2.12 SUV （n=3）。乳头状癌的MET摄取分别为3.40 SUV （n=2）和3.8([SY.+-]] 0.70 SUV （n=3）。因此，与正常甲状腺相比，甲状腺肿瘤的糖代谢和氨基酸代谢均增加。在肿瘤切除术后复发的患者中，乳头状癌的FDG摄取为4.40([SY.+-]])3.04 SUV (n=14)，滤泡癌为4.62 SUV （n=2）。乳头状癌MET摄取分别为2.90 SUV （n=1）和7.80 SUV （n=1）。因此，与正常甲状腺相比，复发甲状腺癌的糖代谢和氨基酸代谢均有所增加。我们比较了FDG-PET和i -131显像对10例甲状腺癌的检测，其中4例复发性癌，6例无复发性癌。FDG-PET的灵敏度、特异度和准确度分别为100%、100%和100%，而I-131闪烁成像的灵敏度、特异度和准确度分别为50%、0%和30%。总之，FDG-PET测量葡萄糖代谢和MET-PET测量氨基酸代谢对甲状腺肿瘤的鉴别诊断都是有用的。FDG-PET对甲状腺癌复发的诊断效果优于I-131显像。

1.We measured both a glucose metabolism and an amino acid metabolism of the normal thyroid gland in healthy volunteers by using positron emission tomography (PET) with F-18-fluorodeoxyglucose (FDG) and C-11-methionine (MET), respectively. The FDG uptake of the normal thyroid gland was 0.97(]SY.+-。[)0.20 SUV (n=5), and the MET uptake of that was 1.02(]SY.+-。[)0.29 SUV (n=3).2.In newly diagnosed patients with thyroid tumor, the FDG uptake of papillary carcinoma was 6.68 SUV (n=2) and that of follicular adenoma 2.12(]SY.+-。[)0.36 SUV (n=3).The MET uptake of papillary carcinoma was 3.40 SUV (n=2) and 3.8(]SY.+-。[)0.70 SUV (n=3). Thus, both the glucose metabolism and the amino acid metabolism of thyroid tumor were increased in comparison with those of the normal thyroid gland.3.In patients with recurrent tumor after the resection, the FDG uptake of papillary carcinoma was 4.40(]SY.+-。[)3.04 SUV (n=14) and that of follicular carcinoma 4.62 SUV (n=2). The MET uptake of papillary carcinoma was 2.90 SUV (n=1) and 7.80 SUV (n=1). Thus, both the glucose metabolism and the amino acid metabolism of recurrent thyroid carcinoma were increased in comparison with those of the normal thyroid gland.4.We compared the FDG-PET and I-131scintigraphy for the detection of thyroid cancer in 10 patients consisting of 4 with recurrent carcinoma and 6 without. The sensitivity, specificity and accuracy of the FDG-PET was 100%, 100% and 100%, respectively, while those of the I-131 scintigraphy 50%, 0% and 30%, respectively.5.In conclusion, both the FDG-PET for measuring a glucose metabolism and the MET-PET for measuring an amino acid metabolism were useful for the differential diagnosis of thyroid tumors. Furthermore, the FDG-PET was superior to the I-131 scintigraphy for the detection of the recurrent thyroid cancer.