Role of No-cGMP system on blockade of descending inhibitory system by anesthetics in spinal code

No-cGMP 系统在脊髓麻醉药阻断下行抑制系统中的作用

• 批准号: 14571427
• 负责人: KATOH Taksumi
• 金额: $ 2.18万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571427/
• 关键词: postoperative paine; inhalational anesthetics; neuropathy; hypersensitivity; descending inhibitory system; 下向性抑制; 一酸化窒素; 疼痛過敏; ハロタン; MAC

It appeals against a postoperative pain strongly immediately after an operation especially for less than 8 hours in many cases. It is suggested that the transfer system of NO-cyclic guanosine monophosphate (cGMP) has played the important role about anesthesia or painkilling. A possibility that an inhalation anesthetic will start consciousness hypersensitivity by low concentration is suggested. this consciousness--the descending control interception by the anesthetic drug in a spine is considered as one of the mechanisms about sensitive generating and its continuation. NOS inhibitor and 7-nitroindazole (7-NI) are HAROTAN by the research by the preceding year. MAC and Righting reflex ED50 It turned out that it influences to (RR). In the naked eye by operation, the damage on the peripheral nerve which is not visible is not avoided. Generating consciousness hypersensitivity not only according to an inhalation anesthetic but according to the obstacle of a peripheral nerve is known. Sharp pa … More in hypersensitivity by the obstacle of a peripheral nerve can also consider that the sharp pain control mechanism in a spine does not work effectively as a cause of the generating. the sharp pain according [we] to an inhalation anesthetic--the sharp pain according being sensitive to damage on a peripheral nerve--in order to investigate a sensitive common mechanism, a new sharp pain sensitive model was developed. The conventional Chung's and others method was the approach to the spinal nerves from a back side, and a possibility of having caused damage on a thin nerve in the operation process was high, and had caused sharp pain hypersensitivity in the operation opposite side. Even if consciousness hypersensitivity by the side of an operation half object happens in the approach from our abdominal side, it is small, and it turned out that it is advantageous in order to clarify descending control interception in a spine this time. the operation of the nerve damage by the approach from the back which we performed as a result of examining the data of the preceding year in detail--the conventional Chung's and others method, and control--consciousness--the big difference had arisen in the sensitive grade. Since this phenomenon was not produced in the approach from a hypersensitivity side, this operation might not necessarily be the model and same of Chung, the necessity of redoing the operation from the back again came out, and this fiscal year redid it. the result--control--consciousness--the difference has still arisen in the sensitive grade. It was suggested that the fundamental difference may have produced this immediately after an operation by the difference in the operation method. Less

它呼吁对术后疼痛强烈立即手术后，特别是在许多情况下不到8小时。提示NO-环磷酸鸟苷（cGMP）转运系统在麻醉或镇痛中起重要作用。提示吸入麻醉剂在低浓度时可能引起意识超敏反应。这种意识--麻醉药物在脊柱中的下行控制拦截被认为是敏感产生及其持续的机制之一。NOS抑制剂和7-硝基吲唑（7-NI）是前一年研究的HAROTAN。结果表明，MAC和翻正反射ED_（50）对RR有影响。在肉眼操作时，不可避免地会对周围神经造成不可见的损伤。已知不仅根据吸入麻醉剂而且根据周围神经的障碍产生意识超敏反应。锐化页 ...更多信息 在由周围神经的障碍引起的超敏反应中，也可以认为脊柱中的剧痛控制机制不能有效地起作用是产生的原因。吸入麻醉剂引起的剧痛--对周围神经损伤敏感的剧痛--为了研究敏感的共同机制，开发了一种新的剧痛敏感模型。传统的Chung等人的方法是从背侧接近脊神经，并且在手术过程中对细神经造成损伤的可能性很高，并且在手术对侧造成剧痛过敏。即使在从我们的腹部侧的方法中发生操作半对象侧的意识超敏反应，它也很小，并且事实证明，这一次为了澄清脊柱中的下行控制拦截是有利的。我们详细检查了前一年的数据，结果从背部入路进行了神经损伤手术--传统的钟氏和其他方法，以及控制--意识--敏感等级出现了很大的差异。由于这一现象不是在从过敏侧的方法中产生的，这次操作不一定是钟的模式和相同，从后面重做操作的必要性再次出现，本财政年度重做了它。结果-控制-意识-敏感等级仍然出现了差异。有人认为，根本的差异可能是由于手术方法的差异而在手术后立即产生的。少