Basical and Clinical Study of Viral Labyrinthitis

病毒性迷路炎的基础与临床研究

• 批准号: 14571601
• 负责人: FUKUDA Satoshi
• 金额: $ 2.05万
• 依托单位: HOKKAIDO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571601/
• 关键词: human inner ear; cochlea; viral labyrinthitis; mumps; hearing loss; 内耳ウイルス感染; ムンプス難聴; ムンプス不顕性感染; 抗ムンプスIgM抗体; 予防接種; 突発難聴; 潜伏感染・再活性化; ヘルペスウイルス; 突発性難聴

We could not get enough number of human autopsy specimen of sensory ganglia within temporal bone, because the decreased number in actual autopsy, especially in intracranial dissection including temporal bone region. Recent stream of tough and precise informed consent makes it more difficult to get the human deep tissue like cochlea. So, we focused on clinical study of mumps hearing loss as follows.The anti-IgM antibody titer was high enough 5.1-14.22(Ave.10.415) in patients with hearing loss by obvious mumps infection.After the measurement of anti-IgM antibody for mumps enabled to diagnose a silent mumps infection, and almost 7-8% of so-called "sudden deaf ness" revealed to be due to a silent mumps infection.Almost 10% of cases showed negative for both anti-mumps IgM and IgG antibody indicating that they were naive for mumps virus.Because mumps often occurs without clinical symptoms, mumps is considered to be still one of the important causes of profound hearing loss. From the viewpoint of prophylaxis of profound hearing loss and deaf ness, care must be taken to understand the situation of virus epidemiology and vaccination.Further human temporal bone study is required using autopsy or ultra-low temperature preserved donation body after death to get better understanding of viral infection of the inner ear.

在实际尸检中，特别是在包括颞骨区在内的颅脑解剖中，由于标本数量的减少，我们无法获得足够数量的人类颞骨感觉神经节尸检标本。最近严格而精确的知情同意使获取人类深层组织(如耳蜗骨)变得更加困难。因此，我们对腮腺炎听力损失的临床研究主要集中在以下几个方面。在有明显腮腺炎感染的听力损失患者中，抗IgM抗体效价高达5.1~14.22(平均10.415)。检测腮腺炎的抗IgM抗体后，可以诊断为无症状的腮腺炎感染，几乎7%-8%的所谓突聋是由于无症状的腮腺炎感染所致。近10%的病例抗腮腺炎IgM和抗体均为阴性，表明它们对腮腺炎病毒是幼稚的。由于腮腺炎经常发生，没有临床症状，腮腺炎仍被认为是严重听力损失的重要原因之一。从预防重度听力损失和聋人的角度出发，必须注意了解病毒流行病学和疫苗接种的情况。进一步的人类颞骨研究需要利用身体解剖或死后超低温保存的供体，以更好地了解内耳的病毒感染情况。

项目成果

Ohtani F. et al.: "Analysis of varicella-zoster virus load and cochleovestibular symptoms in patients with Ramsay Hunt syndrome."Facial N Res Jpn.. 23. 92-94 (2003)

Ohtani F. 等人：“拉姆齐亨特综合征患者的水痘带状疱疹病毒载量和耳蜗前庭症状的分析。”Facial N Res Jpn.. 23. 92-94 (2003)

Matsumura M. et al.: "A case of spontaneous intracranial hypotension with low-tone hearing loss and disequilibrium."Otolaryngol Head Neck Surg. 75. 735-738 (2003)

Matsumura M. 等人：“自发性颅内低血压伴低音听力损失和失衡的病例。”耳鼻喉头颈外科。

松村道哉 他: "低温障害型感音難聴とめまいを呈した突発性低随液圧症候群の1例"耳喉頭頸. 75. 735-738 (2003)

Michiya Matsumura 等人：“一例伴有寒冷引起的感音神经性听力损失和头晕的特发性低液压综合征”Oolaryngology and Neck 75. 735-738 (2003)。

Fukuda S.: "Viral labyrinthitis."Otolaryngol Head Neck Surg. 74. 668-676 (2002)

Fukuda S.：“病毒性迷路炎”。耳鼻喉头颈外科。

Kuroda T. et al.: "A case of Ramsay Hunt syndrome presenting multiple cranial nerve dysfunctions and spinal radiculitis."Facial Nerve Research. 23. 149-151 (2003)

Kuroda T. 等人：“拉姆齐亨特综合征一例，表现为多种脑神经功能障碍和脊神经根炎。”面部神经研究。