Suppression of exercise-induced anaphylaxis by intake allergen with some food components

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Ovalbumin(OVA) sensitized BALB/c mice or lysozymes(Ly) sensitized B10.A mice were used to investigate the mechanisms of food dependent exercise-induced anaphylaxis. Anaphylaxis symptoms of OVA sensitized mice were clearly observed after OVA injection orally and acute exercise responsibility than that of mice treadmill exercised without OVA administration. Allergen was leaked through gastrointestinal damages and reached to a liver of Ly-sensitized mice after Ly injection orally and acute exercise responsibility than unsensitized mice. Anaphylaxis is required to evaluate the systemic symptoms, and is scored by observation of some typical symptoms such as scratching, rubbing and cyanosis. However, the scoring depends on subjective observation, resulting in the poorly quantitative evaluation for anaphylaxis rarely. Locomotion and voluntary physical activity of sensitized mice were examined for 15hr. Voluntary physical activity of sensitized mice was significantly decreased after Ly injection orally and acute exercise responsibility as same as locomotion decrease. The correlation between the symptoms scoring of anaphylaxis and rectal temperature or voluntary physical activities of the mouse was recognized in sensitized mouse model.Long time injection of pectin or a lactic acid drink to sensitized mice was suppressed their voluntary physical activity decrease. These results suggested that pectin or a lactic acid drink have protective effect for sensitized mice symptoms of anaphylaxis.