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Analysis of Th1, Th2, Tc1 and Tc2 cells of patients with otolaryngological diseases.

耳鼻喉科疾病患者Th1、Th2、Tc1、Tc2细胞分析

基本信息

批准号：
16591697
负责人：
OHTA Nobuo
金额：
$ 1.86万
依托单位：
Yamagata University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16591697/
关键词：
Th1 Th2 Tc1 Tc2 allergic rhinitis

项目摘要

Cytokines are important regulatory mediators secreted by T cells and other immunoactive cells. Based on the cytokine synthesis patterns, CD4 T cells can often be classified into at least two populations with different immune regulatory functions. Th1 cells, producing IL-2 and IFN-γ, are often associated with cell-mediated immune responses such as DTH, whereas Th2 cells, secreting IL-4, IL-5, IL-13, usually provide B cell help and enhance allergic reactions. Naive CD8 T cells, similar to CD4 T cells, can differentiate into at least two subsets of cytolytic effector cells with distinct cytokine patterns. Tc1 cells secrete a Th1-like cytokine pattern, including IL-2 and IFN-γ^^~. Tc2 cells produce Th2 cytokines, including IL-4, IL-5 and Il-10. There is increasing evidence that Th1/Th2 and Tc1/Tc2 cytokine imbalance has been of pathogenetic importance in various diseases, such as allergic and autoimmune diseases. The present review article focuses on the evidence that the imbalance of Th1/Th2 and Tc1/Tc2 cytokines play important role in various otolaryngological diseases, such as Kimura's disease, Wegener's granulomatosism, acute perceptive hearing loss and Menier's disease. It is concluded that the predominance of Th1 and Th2 and Tc1 and Tc2 cells might contribute to the mechanism in pathogenesis of these otolaryngological diseases.

细胞因子是由T细胞和其他免疫活性细胞分泌的重要调节介质。根据细胞因子的合成模式，CD 4 T细胞通常可以分为至少两个具有不同免疫调节功能的群体。产生IL-2和IFN-γ的Th 1细胞通常与细胞介导的免疫应答如DTH相关，而分泌IL-4、IL-5、IL-13的Th 2细胞通常提供B细胞帮助并增强过敏反应。与CD 4 T细胞类似，初始CD 8 T细胞可以分化成具有不同细胞因子模式的至少两个溶细胞效应细胞亚群。Tcl细胞分泌Thl样细胞因子模式，包括IL-2和IFN-γ。Tc 2细胞产生Th 2细胞因子，包括IL-4、IL-5和IL-10。越来越多的证据表明，Th 1/Th 2和Tc 1/Tc 2细胞因子失衡在各种疾病，如过敏性疾病和自身免疫性疾病中具有重要的发病机制。本文就Th 1/Th 2和Tc 1/Tc 2细胞因子失衡在Kimura病、Wegener肉芽肿病、急性感觉性聋和Menier病等耳鼻咽喉疾病中的作用进行综述。提示Th 1、Th 2和Tc 1、Tc 2细胞的优势可能参与了这些耳鼻咽喉疾病的发病机制。