Identification and functional analysis of the sensor system involved in behavioral regulation of larvae of digenic platyhelminthes.

为了揭示双殖吸虫的感受器系统，我们分析了血吸虫尾蚴的可能感受器。血吸虫尾蚴亚油酸对Manosini有强烈的吸引作用，并在尾蚴表面检测到负责任的传感器。为了验证这些可能的感受器的直接作用，将RNA干扰技术应用于尾蚴的研究。RNAi在尾蚴阶段仍有技术问题需要解决。目前的研究结果似乎导致试剂的开发，以避免针对皮肤穿透的尾蚴感染。

In the hope of uncovering sensor system of digenic platyhelminthes, we analyzed possible sensor organs of cercariae Schistosoma manosin. Cercariae of S. manosini were strongly attracted by linoleic acid and the responsible sensor seemed to be detected on the surface of cercariae. It was needed to test the direct effects of the probable sensors, and RNAi was applied for schistosoma cercariae. There are still technical matters left for RNAi at the cercarial stage. Results of the current study seem to lead development of reagents to avoid schistosomal infection targeting the skin penatration of cercariae.