Identification and functional analysis of the sensor system involved in behavioral regulation of larvae of digenic platyhelminthes.

为了揭示二源性扁形线虫的传感系统，我们对日本血吸虫尾蚴可能的传感器官进行了分析。马诺氏血吸虫尾蚴对亚油酸有较强的引诱作用，其感受器似乎位于尾蚴表面。需要测试可能传感器的直接效果，并将RNAi应用于血吸虫尾蚴。在尾蚴阶段，仍有技术问题有待RNAi处理。目前的研究结果似乎引导了针对尾蚴皮肤惩罚的试剂的开发，以避免血吸虫感染。

In the hope of uncovering sensor system of digenic platyhelminthes, we analyzed possible sensor organs of cercariae Schistosoma manosin. Cercariae of S. manosini were strongly attracted by linoleic acid and the responsible sensor seemed to be detected on the surface of cercariae. It was needed to test the direct effects of the probable sensors, and RNAi was applied for schistosoma cercariae. There are still technical matters left for RNAi at the cercarial stage. Results of the current study seem to lead development of reagents to avoid schistosomal infection targeting the skin penatration of cercariae.