The study of pathogenesis and related molecules of IgG4 related disease and development of treatment modality.

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IgG4-related sclerosing sialadenitis is a recently recognized disease entity characterized by high serum IgG4 concentration and IgG4-producing plasma cell expansion in affected organs, which show fibrotic or sclerotic changes. However, little is known about the roles of CD4+ and CD8+ T cells or IL-17 in this disease. The purpose of this study was to evaluate the characteristics of CD4+ and CD8+ T cells and IL-17 in patients with IgG4-related sclerosing sialadenitis. Our findings revealed a predominance of Th1 and Tc1 cells and overexpression of IL-17 in patients with IgG4-related sclerosing sialadenitis. This observation emphasizes the involvement of Th1 and Tc1 cells and IL-17 in the pathogenesis of this disease. Identify their precise functional properties would greatly enhance our understanding of their pathogenetic roles. A detailed phenotypic and functional analysis of these subsets is warranted.