5-aminolevulinic acid mediated photodynamic therapy for oral precancerous lesions
5-氨基乙酰丙酸介导的光动力疗法治疗口腔癌前病变
基本信息
- 批准号:16591990
- 负责人:
- 金额:$ 2.18万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2004
- 资助国家:日本
- 起止时间:2004 至 2006
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
5-aminorevulinic acid was administered topically to the tongue of rabbit. Even when medicine was washed away about 10 minutes after topical application, protoporfirin IX accumulated to almost same degree with conventional application methods. Fluorescence micrography to evaluate drug localization revealed that protoporfirin accumulate mucosal basal layer. The result suggest that 5-aminorevulinic acid mediated photodynamic therapy will be efficient therapy for oral leukoplakia.
5-将氨基雷维酸局部施用于兔的舌头。即使当药物在局部施用后约10分钟被洗掉时,原卟啉IX的积累程度与常规施用方法几乎相同。荧光显微成像评价药物定位显示原卟啉积聚在粘膜基底层。结果提示,5-氨基阿维啉酸介导的光动力学疗法是治疗口腔白斑的有效方法。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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TANAKA Hideo其他文献
TANAKA Hideo的其他文献
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{{ truncateString('TANAKA Hideo', 18)}}的其他基金
Roles of T tubular distribution in genesis of atrial fibrillation
T管分布在心房颤动发生中的作用
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$ 2.18万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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19310053 - 财政年份:2007
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$ 2.18万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Role of Abnormal Intracellular Calcium Dynamics in the genesis of electrical alternans in the heart
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17310042 - 财政年份:2005
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Research of the relationship between the enlightenment and formation of political economy in modern England and its Anglo-phone sphere
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16203013 - 财政年份:2004
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$ 2.18万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
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