Genome science towards the understanding of life

基因组科学有助于理解生命

• 批准号: 12201001
• 负责人: KOHARA Yuji
• 金额: $ 2079.17万
• 依托单位: National Institute of Genetics
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12201001/
• 关键词: Genome Sequencing; EST; Resources; Outreach; モデル生物; 計算機モデル化; 遺伝子機能; 脊椎動物進化; 比較ゲノム; 霊長類ゲノム; 発生進化; アウトリーチ活動; 産学連携; ヒト多型タイピング; ESTシーケンシング; 多型タイピング; マイクロサテライト; SNPs; 医科学倫理問題

As the managing group of the 4 areas (this area and the other 3 genome areas), it performed the following activities;1) Coordination among this 4 areas2) Research resources; The DNA sequencing committee has performed genome sequencing of red algae (Cyanidioschyzon merolae), Ascidian (Ciona intestinalis), Y chromosome of liverwort (Marchantia polymorpha L), Medaka fish (Oryzias latipes) and wild mouse derived strain MSM by the whole genome shotgun strategy together with the end sequencing of fosmid and BAC clones. It also performed EST sequencing of nematode worms (Caenorhabditis elegans and Diploscapter sp.), Ascidian (Ciona intestinalis, Ciona savignyo and Halocynthia roretzi), Hagfish (Eptatretus burgeri), Medaka fish (Oryzias latipes), ciclid fish (Haplochromis chilotes), loach (Misgurnus anguillicaudatus), frog (Xenopus laevies), slime mold (Dictyostelium discodeum), red algae (Cyanidioschyzon merolae), moss (Physcomitrella patens subsp. patens), barley, wheat (Triticim aestivum cv. Chinese Spring), Japanese morning glory. The resource committee distributed the clones analyzed above to all over the world.3) Outreach; The publicity committee provided information on the 4 areas to the public and research community. The social relationship committee held a social event named "Genome Square" altogether 8 times (in Tokyo, Kyoto and Fukuoka) during last 3 years, in which the research groups in the 4 areas presented their posters and research materials to communicate with the general public. The committee also discussed on the ethics issue in genome medicine.

作为四个区域的管理小组（本领域和其他3个基因组领域），它进行了以下活动：1）协调这4个领域2）研究资源; DNA测序委员会对红藻进行了基因组测序（Cyanidioschyzon merolae），海鞘（玻璃海鞘），苔类植物的Y染色体（Marchantia polymorpha L.）、青鳉鱼（Oryzias latipes）和野生小鼠来源的MSM品系。它还进行了蠕虫（秀丽隐杆线虫和双头线虫）的EST测序，海鞘（玻璃海鞘（Ciona savignyo）和Halocynthia roretzi）、盲鳗（Eptatretus burgeri）、青鳉鱼（Oryzias latipes）、金线鱼（Haplochromis chilotes）、泥鳅（Misgurnus anguillicaudatus）、蛙（Xenopus laevies）、黏菌（Dictyosteophordiscodeum）、红藻（Cyanidioschyzon merolae）、苔藓（小立碗藓（Physcomitrella patens subsp. patens）、大麦、小麦（Triticim aestivum cv.中国春）、日本牵牛花。资源委员会将上述分析的克隆体分发到世界各地。3）推广;宣传委员会向公众和研究界提供关于4个领域的信息。社会关系委员会在过去的3年里共举办了8次名为“基因组广场”的社会活动（在东京、京都和福冈），其中4个地区的研究小组展示了他们的海报和研究材料，与公众进行了交流。委员会还讨论了基因组医学的伦理问题。

项目成果

Large-scale isolation of ESTs from medaka embryos and its application to medaka developmental genetics

• DOI: 10.1016/j.mod.2004.03.033
• 发表时间: 2004-07-01
• 期刊: MECHANISMS OF DEVELOPMENT
• 影响因子: 2.6
• 作者: Kimura, T;Jindo, T;Takeda, H
• 通讯作者: Takeda, H

Nucleotide sequence comparison of a chromosome rearrangement on the human chromosome 12 and corresponding ape chromosomes

人类12号染色体和相应猿染色体上染色体重排的核苷酸序列比较

• 发表时间: 2005
• 期刊: Cytogenetic and Genome Research 108(1-3)
• 作者: Teiya Kijimoto;et al.;Shimada M et al.
• 通讯作者: Shimada M et al.

Tetsuya Muramoto: "Construction of a gamete-enriched gene pool and RNAi-mediated functional analysis in Dictyostelium discoideum."Mechanisms of Development. 120. 965-975 (2003)

Tetsuya Muramoto：“盘基网柄菌中配子富集基因库的构建和 RNAi 介导的功能分析。”发育机制。

Ohta, N.: "Complete sequence and analysis of the plastid genome of the unicellular red alga CyanidiosChyzon merolae"DNA Research. (in press). (2003)

Ohta, N.：“单细胞红藻 CyanidiosChyzon merolae 质体基因组的完整序列和分析”DNA 研究。

magp4 gene may contribute to the diversification of cichlid morphs and their speciation

• DOI: 10.1016/j.gene.2006.01.016
• 发表时间: 2006-05-24
• 期刊: GENE
• 影响因子: 3.5
• 作者: Kobayashi, Naoki;Watanabe, Masakatsu;Okada, Norihiro
• 通讯作者: Okada, Norihiro