Expression-pattern based studies on gene regulation network in the nemetode C.elegans

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We have found the cis- and trans-elements for the localization of pos-1 mRNA to the posterior side and mex-3 mRNA to the anterior side in the 2 cell stage embryo of C.elegans, and have obtained the clue to understand the mechanisms of mRNA localization. 2) Based on the analysis of β-catenin HMP-2 in C.elegans early embryos, we have proposed that HMP-2 functioned downstream of the Src signaling pathway and contributed to endoderm induction and ABar spindle orientation, in parallel with the Wnt signaling pathway. 3) We identified the regions of promoter activity for gcy-8 and gcy-18 , essential genes for the thermosensory neuron AFD, and found that the transcription factors CEH-11 and TTX-1 functioned in the regulation of the gene expression coordinately