Studies on signaling molecules that regulates dynamics of neural network formation

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Neural circuits are formed by the combined actions of extracellular signals that regulate cell differentiation, axon guidance, and synaptogenesis. In this study, we focus on novel sulfatases (SulfFP1 and SulfFP2) that hydrolyzes 6-O-sulfate in the heparan sulfate chain, and also on Enpp2 involved in extracellular production of lysophosphatidic acid. We have shown that dynamic regulation of heparan sulfate and lipid mediators plays important roles in neural development.