Analysis of the ubiquitin ligase complexes that regulates the transcription of nuclear receptors.

我们注意到核受体是连接DECODE网络和DECODE复合物的因素，并试图分析其转录调控机制，发现CHIP（一种U-box型泛素连接酶）参与雌激素受体（ER）的降解，并且CHIP具有肿瘤抑制作用。此外，我们发现ER通过招募未知的泛素连接酶到Smad复合物来促进Smad的降解。我们还鉴定了一种新的核仁蛋白Nucleomethylin（NML）和一种新的将能量信号与DECODE网络连接的蛋白质复合物eNoSC。

We notice the nuclear receptors as factors that connect DECODE networks with DECODE complex, and tried to analyze the transcriptional regulations.We have found that CHIP, a U-box-type ubiquitin ligase, is implicated in degradation of estrogen receptor (ER), and that CHIP has tumor suppressive role. Moreover, we found that ER promotes Smad degradation by recruiting unknown ubiqutin ligase(s) to Smad complex. We also identified Nucleomethylin (NML),a novel nucleolar protein, and eNoSC, a novel protein complex that connect energy signal with DECODE network..