Regulation mechanism of biosynthesis, intracellular localization and degradation of membrane transporters

我们研究了自噬降解的调节以及烟草SCAMP的细胞内定位和降解，SCAMP是一种膜转运蛋白，还有烟草的蔗糖转运蛋白和拟南芥的硼酸盐转运蛋白。通过对SCAMP的分析，我们发现了一种新的细胞内结构。我们还在蔗糖转运蛋白和硼酸盐转运蛋白降解的营养调控方面获得了新的机制见解。

We investigated the regulation of autophagic degradation as well as the intracellular localization and degradation of tobacco SCAMP, which is known as an escort protein of membrane transporters, as well as sucrose transporters from tobacco and a borate transporter from Arabidopsis. We found a novel intracellular structure through the analysis of the SCAMP. We also got novel mechanistic insights on the nutritional regulation of the degradation of both sucrose transporters and the borate transporter.