High resolution ESI mass spectrometer for high throughput accurate mass determination

七个研究小组，他们处理现代合成的不同领域的合成方法的发展，参与这个应用程序。他们的研究导致了大量的样本进行分析。质量的短期测定对于方法的控制和优化是绝对必要的。此外，新化合物的精确质量的测定同时也要求在高级期刊上发表。所要求的仪器将安装在有机化学研究所质谱中心部门，用于分析和表征新化合物。目前，电喷雾电离（ESI）和电子电离（EI）仪器可用于精确测定质量。一台ESI质谱仪从2020年2月开始出现故障，由于成本原因一直没有维修。ESI精确的质量测量目前在两台仪器上进行。其中一个必须从研究所的资金中购买，作为有缺陷的仪器作为廉价的二手仪器的紧急替代品。然而，这两种仪器都已经使用了12年以上，因此需要一种新的高性能仪器来用于高通量，以应对来自相关研究小组的大量样品。此外，2021年另一种旧的LC-MS系统的缺陷使得这种替换变得紧迫，因为LC-MS目前必须在其他大量使用的ESI仪器的常规分析之外进行。

Seven research groups, which deal with the development of synthetic methods in different areas of modern synthesis, participate in this application. Their studies lead to a large number of samples to be analyzed. The short-term determination of the mass is absolutely essential for the control and optimization of methods. Furthermore, the determination of the accurate masses of new compounds is meanwhile required for publication in high-ranking journals. The requested instrument will be installed in the central department for mass spectrometry in the Organic Chemistry Institute for the analysis and characterization of novel compounds. Instruments with electrospray ionization (ESI) and electron ionization (EI) are currently available for determination of accurate masses. One ESI mass spectrometer is out of order since 2/2020 and has not been repaired for reasons of cost. ESI accurate mass measurements are currently conducted on two instruments. One of them had to be procured from institute funds as an urgent replacement for the defective instrument as an inexpensive used instrument. Both instruments, however, are already more than 12 years old, so that a new, high-performance instrument is required for use in high throughput in order to cope with the high number of samples from the involved research groups. Further, the defect of another older LC-MS system in 2021 makes this replacement urgent, since LC-MS currently has to be carried out in addition to the routine analysis on the other heavily used ESI instruments.