Novel ESI-MS interface with increased sensitivity
新型 ESI-MS 接口,灵敏度更高
基本信息
- 批准号:7670880
- 负责人:
- 金额:$ 7.66万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-09-30 至 2010-07-06
- 项目状态:已结题
- 来源:
- 关键词:AirAtmospheric PressureBasic ScienceBiologicalChargeChemicalsComplex MixturesCouplingDevelopmentDigestionElectrospray IonizationGasesHeatingIonsLiquid ChromatographyLiquid substanceMass Spectrum AnalysisNoiseOperative Surgical ProceduresPeptidesPlayPost-Translational Protein ProcessingPrincipal InvestigatorProceduresProtein AnalysisProteinsProteomicsResearchResolutionRoleSolutionsSourceSpecificitySpeedTechniquesVacuumWaterbasechemical eliminationclinical applicationdrug discoveryimprovedinnovationion sourceionization techniquemass spectrometermicrowave electromagnetic radiationnovelplanetary Atmospherepressurepublic health relevancetandem mass spectrometrytool
项目摘要
DESCRIPTION (provided by applicant): The primary objective of this proposal is to develop a novel electrospray ion source operating inside the mass spectrometer, based on internal heating of small droplets and water clusters. The use of internal heating (contrary to external one by ambient gas) of micro-droplets will allow using electrospray at reduced pressures inside the mass spectrometer. Such an introduction of ions will be much more efficient compared to conventional one which uses atmospheric pressure-vacuum interface. The efficient desolvation by internal heating, the absence of ion loss pertinent to conventional atmospheric pressure-vacuum interfaces, and elimination of the chemical noise originated from chemical impurities present in the ambient air are expected to substantially increase the sensitivity of the ESI-MS. PUBLIC HEALTH RELEVANCE: The application of mass spectrometry as a proteomics tool plays an important role in modern basic science, drug discovery and clinical applications. A novel electrospray ion source with enhanced sensitivity will further increase the speed and specificity of protein analysis.
描述(由申请人提供):本提案的主要目的是开发一种基于小液滴和水簇的内部加热在质谱仪内操作的新型电喷雾离子源。微滴的内部加热(与通过环境气体的外部加热相反)的使用将允许在质谱仪内部的减压下使用电喷雾。与使用大气压-真空界面的传统方法相比,这种离子的引入将更加有效。通过内部加热进行有效的去溶剂化、不存在与常规大气压-真空界面相关的离子损失以及消除源自环境空气中存在的化学杂质的化学噪声,预期将大幅提高ESI-MS的灵敏度。质谱技术作为蛋白质组学的一种工具,在现代基础科学、药物发现和临床应用中发挥着重要作用。具有增强灵敏度的新型电喷雾离子源将进一步提高蛋白质分析的速度和特异性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('VADYM D BERKOUT', 18)}}的其他基金
A novel ion source for efficient coupling of liquid chromatography and mass spect
用于高效耦合液相色谱和质谱的新型离子源
- 批准号:
8057752 - 财政年份:2011
- 资助金额:
$ 7.66万 - 项目类别:
Novel ESI-MS interface with increased sensitivity
新型 ESI-MS 接口,灵敏度更高
- 批准号:
8179073 - 财政年份:2011
- 资助金额:
$ 7.66万 - 项目类别:
A novel fragmentation technique for tandem mass spectrometry
一种用于串联质谱分析的新型裂解技术
- 批准号:
7996740 - 财政年份:2010
- 资助金额:
$ 7.66万 - 项目类别:
Electron-Transfer Dissociation Tandem Mass Spectrometry
电子转移解离串联质谱法
- 批准号:
7480633 - 财政年份:2006
- 资助金额:
$ 7.66万 - 项目类别:
Electron-Transfer Dissociation Tandem Mass Spectrometry
电子转移解离串联质谱法
- 批准号:
7691766 - 财政年份:2006
- 资助金额:
$ 7.66万 - 项目类别:
A Novel Method of Ion Fragmentation in Tandem Mass Spectrometry
串联质谱中离子断裂的新方法
- 批准号:
7414572 - 财政年份:2006
- 资助金额:
$ 7.66万 - 项目类别:
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