Construction of the heart rehabilitation system by the assisted artificial heart which aimed at the cardiac functional recovery of serious heart failure

针对严重心力衰竭心功能恢复的辅助人工心脏心脏康复体系构建

• 批准号: 21249073
• 负责人: NISHIMURA Takashi
• 金额: $ 28.45万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21249073/
• 关键词: 補助人工心臓; bridge to recovery; 心臓リハビリテーション; 心不全; 心筋酸素消費量

We have been developed Native Heart Load Control System(NHLCS) through this project, which can control the load on the native heart by controlling the pump drive state in synchronization with the heartbeat. This system was confirmed that it is possible to drive to follow suit to arrhythmia and heart rate changes on the acute animal experiments. Moreover, this system was confirmed to be effective on the chronic heart failure animal model. In addition, it was also been found that may increase coronary blood flow in this drive system, which is also expected to be a novel ischemic heart failure treatment. And it also may increase pulsatile arterial pressure in systemic blood flow by driving the system. Currently, including the additive effect of these various, mounted to the actual future artificial heart has been expected.

通过本项目开发的原生心脏负荷控制系统（NHLCS），可以通过控制泵驱动状态与心跳同步来控制原生心脏负荷。该系统在急性动物实验中证实了对心律失常和心率变化进行驱动跟踪的可行性。此外，该系统在慢性心力衰竭动物模型上被证实是有效的。此外，还发现可能增加该驱动系统的冠状动脉血流量，这也有望成为一种新的缺血性心力衰竭治疗方法。它还可能通过驱动系统来增加全身血液流动中的脉动动脉压。目前，包括这些各种叠加效应在内，未来安装到实际的人工心脏已经是可望而不可及。

项目成果

The change of coronary flow by controlling the power of continuous-flow left ventricular assist device in acute heart failure : Counterpulse drive mode can increase the coronary flow.

急性心力衰竭时控制连续流左心室辅助装置功率改变冠脉流量：反脉冲驱动方式可增加冠脉流量。

• 发表时间: 2011
• 作者: Umeki A;Takewa Y;Nishimura T;Ando M;Mizuno T;Tsukiya T;Ono M;Kyo S;Yamazaki K;Taenaka Y;Tatsumi E.
• 通讯作者: Tatsumi E.

Electrocardiogram-synchronized rotational speed change mode in rotary pupscould improve pulsatility

旋转小狗中的心电图同步转速变化模式可以改善搏动性

• 发表时间: 2011
• 期刊: Artificial Organs
• 影响因子: 2.4
• 作者: Ando M;Nishimura T;etal.
• 通讯作者: etal.

Current Therapy with VAD for Severe Heart Failure Patients in Japan

目前日本严重心力衰竭患者的 VAD 治疗

• 发表时间: 2011
• 作者: 宮田秀俊;谷口英樹;Takashi Nishimura
• 通讯作者: Takashi Nishimura

Preoperative Lower Left Ventricular Ejection Fraction and Implantation of Continuous Flow Pump are Indeinsufficiency in Patients with Left Ventricular Assist Device

左心室辅助装置患者术前左心室下射血分数和连续流泵植入不足

• 发表时间: 2011
• 作者: Masaru Hatano;et al.
• 通讯作者: et al.

心機能の回復を目的とした磁気浮上型治療用血液ポンプの研究開発

以恢复心脏功能为目的的磁悬浮治疗血泵的研发

• 发表时间: 2011
• 作者: 山田悠;他5名
• 通讯作者: 他5名