Effects of Asian sand dust on airway diseases and genetic susceptibility factors for exacerbation of allergic diseases

这项研究表明，亚洲沙尘加重过敏性气道炎症，日本雪松花粉症和特应性皮炎沿着在实验动物研究中的促炎介质的表达。此外，ASD引起炎症转录因子和遗传易感因子的改变，使过敏性疾病加重。ASD加重过敏性气道炎症，沿着气道上皮下层的纤维增厚，而长期致敏减弱这些变化，表明长期致敏可能导致TGF-β介导的免疫耐受。在流行病学研究中，ASD事件加重了有和无变应性鼻炎的年轻人的鼻、眼和咽症状。慢性阻塞性肺疾病（COPD）与ASD的关系未观察到。ASD事件也导致过敏性鼻炎、日本雪松花粉症和哮喘的门诊就诊增加。这些结果表明ASD是一种环境因子，可加剧日本雪松花粉症和哮喘等过敏性疾病。

This study demonstrated that Asian sand dust aggravated allergic airway inflammation, Japanese cedar pollinosis and atopic dermatitis along with the expression of pro-inflammatory mediators in experimental animal studies. Moreover, ASD caused the changes of inflammatory transcription factors and genetic susceptibility factors for exacerbation of allergic diseases. ASD aggravates allergic airway inflammation along with fibrous thickening of the subepithelial layer in the airway, whereas long -term sensitization attenuates these changes, suggesting that long-term sensitization may cause immune tolerance mediated by TGF-β. In epidemiology study, ASD event aggravated nasal, eye and pharygeal symptoms in young adults with and without allergic rhinitis. As for chronic obstructive pulmonary disease (COPD), the relation with ASD was not observed. Also ASD event caused an increase of clinic visits for allergic rhinitis, Japanese cedar pollinosis and asthma. These results suggest ASD is an environmental agent which aggravates allergic diseases including Japanese cedar pollinosis and asth ma.