Generation and characterization of animal models deficient in RNA methylation.

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Experiments with animals genetically deficient in methylation or in which methylations have been pharmacologically inhibited have progressed well, although the high inter-individual variability between animals and poor conditions in our department's animal house has so far prevented us to obtain publication-level results with genetically deficient animals.Nevertheless, pharmacological studies in multiple organisms, in intercontinental collaboration with many laboratories have progressed very well and a new paper titled "Methylation deficiency disrupts biological rhythms from bacteria to humans" has been published in a Nature journal on the 6th of May (Fustin et al., 2020), with two other publications this year (Doi et al., 2019; Fustin et al., 2019)