Elucidation of autophagy in development of periodontitis and its application of therapy

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Various genetic disorders in severe periodontitis are caused by abnormalities of lysosomal-related genes. However, the detailed mechanisms are still unknown. Recently, we have assumed that autophagy is involved in elimination of Porphyromonas gingivalis, a major periodontal pathogen, after infection. In this study, we have elucidated the detailed mechanisms of autophagy in periodontitis, an important issue of dental science, in order to provide clues to the molecular basis of new methods for prevention, diagnosis, and therapy in oral sciences.