A fundamental study of the role of signal transduction pathways in the regulation of Chlamydia's complex developmental cycle.

信号转导途径在衣原体复杂发育周期调节中的作用的基础研究。

• 批准号: DP0449555
• 负责人: Prof Peter Timms
• 金额: $ 16.71万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-07-31 至 2007-07-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0449555
• 关键词: fundamental; study; role; signal; transduction

Chlamydia are unique organisms in the microbial world. They are among the smallest bacteria and yet have a complex two-stage developmental cycle. In addition they are major causes of disease in animals and humans with no vaccines available. We have used the recent flood of full genome sequence data to identify over 30 new cell signalling proteins. By understanding how these cell signaling proteins are organized into pathways and how this microorganism controls its complex growth and developmental cycle, we will be able to develop novel methods of control. We are at the fore front of international research and therefore uniquely placed to conduct this project.

衣原体是微生物世界中独特的生物。它们是最小的细菌之一，但具有复杂的两阶段发育周期。此外，它们是导致动物和人类疾病的主要原因，而目前还没有可用的疫苗。我们利用最近大量的全基因组序列数据来鉴定 30 多种新的细胞信号蛋白。通过了解这些细胞信号蛋白如何组织成途径以及这种微生物如何控制其复杂的生长和发育周期，我们将能够开发新的控制方法。 我们处于国际研究的前沿，因此具有独特的优势来开展该项目。