The role of a novel family of Golgi proteins in maintaining the structure and function of the trans-Golgi network
The role of a novel family of Golgi proteins in maintaining the structure and function of the trans-Golgi network
批准号:
DP0450848
负责人:
Prof Paul Gleeson
金额:
$24.65万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2004
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2004-01-13 至 2006-12-31
中文摘要
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英文摘要
The secretory pathway of eukaryotic cells is fundamental for proper cell growth. The Golgi apparatus is a key organelle of this pathway where newly made proteins are selectively packaged into membrane-bound transport vehicles and then shipped to their correct destination, such as the surface of the cell. This research aims to understand the mechanism by which these cargo-loaded transport vehicles are generated from the Golgi apparatus. This information is of fundamental importance in understanding how a cell survives and grows, and is necessary to allow a rational basis for the engineering of secreted recombinant molecules.
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依托单位:
国内基金
海外基金
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