Ultrasensitive all-optical scanner for biomedical photoacoustic tomography and acoustic metrology

用于生物医学光声断层扫描和声学计量的超灵敏全光学扫描仪

• 批准号: 516147140
• 负责人: Professor Jan Laufer, Ph.D.
• 金额: --
• 依托单位: Institut für Physik
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/516147140?language=en
• 关键词: Ultrasensitive; optical; scanner; biomedical; photoacoustic

Biomedical photoacoustic (PA) imaging is a hybrid technique that combines the strong absorption-based contrast with the high spatial resolution of ultrasound to enable functional and molecular imaging. PA tomography, in particular, has been shown to bridge the gap between the microscopic and macroscopic imaging capabilities of more established modalities. A critical goal in the development of this technology are further improvements in image penetration depth, contrast, and frame rate whilst maintaining high spatial resolution. The most promising route to achieving these goals is the development of new acoustic detection technologies that provide greater detection sensitivity. In this project, an all-optical tomograph based on a large aperture Fabry-Pérot etalon will be developed. Using adaptive optics and camera-based detection, this approach has the potential to achieve ultrahigh sensitivity whilst maintaining all advantageous attributes of all-optical ultrasound detection, such as small element sizes and broad frequency response for high spatial resolution, omnidirectional response, and parallelised signal acquisition for high frame rates.

生物医学光声（PA）成像是一种混合技术，它结合了基于吸收的强对比度和超声的高空间分辨率，以实现功能和分子成像。特别是PA断层扫描，已被证明可以弥合更成熟的模式的微观和宏观成像能力之间的差距。该技术发展的一个关键目标是进一步提高图像穿透深度、对比度和帧速率，同时保持高空间分辨率。实现这些目标的最有希望的途径是开发新的声学检测技术，提供更高的检测灵敏度。本计画将研制一台以大口径法布里-珀罗标准具为基础的全光学层析摄影机。使用自适应光学和基于相机的检测，这种方法有可能实现超声波灵敏度，同时保持全光学超声检测的所有有利属性，例如小元件尺寸和宽频率响应以获得高空间分辨率、全向响应和并行信号采集以获得高帧速率。