The role of mechanosensitive (MS) ion channels in magnetoreception.

机械敏感（MS）离子通道在磁接收中的作用。

• 批准号: DP0452128
• 负责人: Prof Boris Martinac
• 金额: $ 21.94万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0452128
• 关键词: role; mechanosensitive; MS; ion; channels

The magnetic field of the Earth has for long been known to influence the behaviour and orientation of a variety of organisms. Experimental study of the magnetic sense has however, been impaired by the lack of a plausible cellular and/or molecular mechanism providing meaningful explanation for detection of magnetic fields by living organisms. Recently, mechanosensitive (MS) ion channels have been implied to play a role in magnetoreception. Based on our preliminary investigations, which suggest that the activity of bacterial MS channels may be affected by magnetic fields, we propose to study effects of magnetic fields on MS ion channels in Gram-negative bacteria Escherichia coli and Magnetospirillum magnetotacticum. The project promises also to contribute towards better understanding of adverse effects of electromagnetic radiation on human health and towards understanding the mechanisms behind remote magnetic-nanoparticle mediated activation of MS ion channels.

人们早就知道地球磁场会影响各种生物体的行为和方向。然而，由于缺乏合理的细胞和/或分子机制，无法为活体生物体检测磁场提供有意义的解释，因此磁感的实验研究受到了损害。最近，机械敏感（MS）离子通道被暗示在磁感受中发挥作用。基于我们的初步研究表明细菌MS通道的活性可能受到磁场的影响，我们建议研究磁场对革兰氏阴性细菌大肠杆菌和磁磁螺菌中MS离子通道的影响。该项目还有望有助于更好地了解电磁辐射对人类健康的不利影响，并有助于了解远程磁性纳米颗粒介导的 MS 离子通道激活背后的机制。