Research Fellowship
Research Fellowship
批准号:
nhmrc : 1044628
负责人:
Prof Boris Martinac
金额:
$50.13万
依托单位国家:
澳大利亚
项目类别:
Research Fellowships
财政年份:
2013
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2013-01-01 至 2017-12-31
关键词:
中文摘要
离子通道是可兴奋膜的分子孔,促进离子和有机溶质穿过细胞膜。越来越多的人类和动物疾病是由于离子通道功能失常而导致的,这些离子通道成为重要的治疗靶点,这些靶点由一系列目前处方的药物调节。近年来,科学和医学界已经越来越意识到机械敏感离子通道在包括心脏肥大和心律失常在内的疾病的病理学中所起的作用。
英文摘要
Ion channels are molecular pores of excitable membranes facilitating passage of ions and organic solutes across cellular membranes. An ever-increasing number of human and animal diseases result from malfunctioning ion channels making them to important therapeutic targets, which are modulated by a range of currently prescribed drugs. In the recent years the scientific and medical community has become increasingly aware of the role that mechanosensitive ion channels play in pathology of diseases including cardiac hyperthrophy and arrhythmias.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Force-from-lipids biophysical principle underlying mechanotransduction
-
批准号:DP200100860
-
项目类别:Discovery Projects
-
资助金额:$61.08万
-
财政年份:2020
-
负责人:Prof Boris Martinac
-
依托单位:
Mechanosensory Biophysics Program
-
批准号:nhmrc : GNT1135974
-
项目类别:Research Fellowships
-
资助金额:$77.45万
-
财政年份:2018
-
负责人:Prof Boris Martinac
-
依托单位:
Mechanosensory Biophysics Program
-
批准号:nhmrc : 1135974
-
项目类别:Research Fellowships
-
资助金额:$52.37万
-
财政年份:2018
-
负责人:Prof Boris Martinac
-
依托单位:
Engineering of a novel export system for industrially important amino acids
-
批准号:DP180102813
-
项目类别:Discovery Projects
-
资助金额:$26.81万
-
财政年份:2018
-
负责人:Prof Boris Martinac
-
依托单位:
Mechanoelectrical transduction in chondrocytes
-
批准号:nhmrc : 1122104
-
项目类别:Project Grants
-
资助金额:$30.1万
-
财政年份:2017
-
负责人:Prof Boris Martinac
-
依托单位:
Molecular force sensing mechanisms of PIEZO channels
-
批准号:DP160103993
-
项目类别:Discovery Projects
-
资助金额:$45.63万
-
财政年份:2016
-
负责人:Prof Boris Martinac
-
依托单位:
Membrane excitability and cellular calcium regulation in the peripheral nervous system under different (patho)-physiological conditions and in inflammatory disease
-
批准号:LX0882427
-
项目类别:Linkage - International
-
资助金额:$6.27万
-
财政年份:2008
-
负责人:Prof Boris Martinac
-
依托单位:
Force from lipids: the role of the lipid bilayer in mechanosensory transduction
-
批准号:DP0769983
-
项目类别:Discovery Projects
-
资助金额:$109.19万
-
财政年份:2007
-
负责人:Prof Boris Martinac
-
依托单位:
Gating, specificity and regulation of the YggB channel protein from Corynebacterium glutamicum.
-
批准号:LX0776077
-
项目类别:Linkage - International
-
资助金额:$1.72万
-
财政年份:2007
-
负责人:Prof Boris Martinac
-
依托单位:
The role of mechanosensitive (MS) ion channels in magnetoreception.
-
批准号:DP0452128
-
项目类别:Discovery Projects
-
资助金额:$21.94万
-
财政年份:2005
-
负责人:Prof Boris Martinac
-
依托单位:
Early evolutionary origins of mechanosensory transduction: structure, function and phylogenetic studies of the family of mechanosensitive channels in cell-walled organisms.
-
批准号:DP0342581
-
项目类别:Discovery Projects
-
资助金额:$40.46万
-
财政年份:2005
-
负责人:Prof Boris Martinac
-
依托单位:
海外基金