Mechanoelectrical transduction in chondrocytes

软骨细胞中的机电转导

• 批准号: nhmrc : 1122104
• 负责人: Prof Boris Martinac
• 金额: $ 30.1万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanoelectrical-transduction-chondrocytes/946870
• 关键词: Mechanoelectrical; transduction; chondrocytes

The cells that produce and maintain our cartilage, known as chondrocytes, do so by sensing changes in the mechanical environment, but precisely how chondrocytes detect these changes is not known. We are investigating the role of ion channels that are opened in direct response to mechanical movements within the cartilage.This project plans to identify the specific molecules that are participating in this process and to determine if they are therapeutic targets for treatment of osteoarthritis

产生和维持软骨的细胞，被称为软骨细胞，通过感知机械环境的变化来实现这一目标，但软骨细胞如何准确地检测这些变化尚不清楚。我们正在研究在软骨内部机械运动的直接反应中打开的离子通道的作用。该项目计划确定参与这一过程的特定分子，并确定它们是否是治疗骨关节炎的治疗靶点