Membrane excitability and cellular calcium regulation in the peripheral nervous system under different (patho)-physiological conditions and in inflammatory disease

不同（病理）生理条件下和炎症性疾病中周围神经系统的膜兴奋性和细胞钙调节

• 批准号: LX0882427
• 负责人: Prof Boris Martinac
• 金额: $ 6.27万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Linkage - International
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LX0882427
• 关键词: Membrane; excitability; cellular; calcium; regulation

Studies of cytokine action on neurons and muscle give new insights into functional responses of the nervous system to systemic inflammation and sepsis. In some countries, sepsis is the third most frequent cause of death following heart attack. Elucidating the pathomechanisms allows to develop therapeutic strategies. Electrophysiology, Ca2+ regulation and optical membrane potentiometry allow us to monitor early changes in disease on a (sub)cellular level. Experiments on Ca2+ regulation and ion channel function in muscle with different cholesterol membrane contents will help to understand pathomechanisms in high cholesterol diseases, e.g. obesity, on the membrane level long before cardiovascular effects become prominent.

细胞因子对神经元和肌肉作用的研究为神经系统对全身性炎症和脓毒症的功能反应提供了新的见解。在一些国家，败血症是心脏病发作后第三大最常见的死亡原因。阐明病理机制允许开发治疗策略。电生理学、Ca2+调节和光学膜电位法使我们能够在（亚）细胞水平上监测疾病的早期变化。在具有不同胆固醇膜含量的肌肉中进行Ca2+调节和离子通道功能的实验将有助于在心血管效应变得突出之前很久就在膜水平上理解高胆固醇疾病（例如肥胖）的病理机制。