Regulation of cellular Function by molecular chaperones

分子伴侣对细胞功能的调节

• 批准号: 09276102
• 负责人: NAGATA Kazuhiro
• 金额: $ 54.78万
• 依托单位: KYOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas (A)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09276102/
• 关键词: molecular chaperone; stress proteins; protein folding; quality control; heat shock proteins; chaperonin; transport; prion; 細胞内輸送; 細胞機能制御; Quality Control

This group tried to well-organize the studies performed among three groups : "Dynamic interaction between chaperone and its substrates", "Roles of molecular chaperones in cell function" and the selected research groups from applicants.1. We held the group meeting twice a year and discussed about the progress of each research as well as perspective and direction of the whole research groups.2. We issued the "Chaperone newsletter" twice a year to stimulate the exchange of the information among the members. In addition to the 9 issues of these newsletters, we also published a special issue on "Chaperone-related ATPases". These newsletters brought broad interest and impact to general readers outside this field.3. We organized a general meeting for all the members every year and active discussion was performed on the progress of each research by the attendants including the members.4. We organized a international congress titled "Molecular Chaperone 2000" in Tokyo and two symposiums and two workshops during these 5 years.

本课题组尝试将“分子伴侣与其底物的动态相互作用”、“分子伴侣在细胞功能中的作用”和申请者选定的研究组三个研究组进行良好的组织。我们每年召开两次小组会议，讨论每项研究的进展以及整个研究小组的观点和方向.我们每年出版两次“伴侣通讯”，以促进成员之间的信息交流。除了这9期通讯外，我们还出版了一份关于“与陪伴有关的ATP”的特刊。这些通讯给该领域以外的普通读者带来了广泛的兴趣和影响。我们每年组织一次全体会员大会，包括会员在内的与会者对每项研究的进展进行积极的讨论.在这5年中，我们在东京组织了一次名为“分子伴侣2000”的国际会议，以及两次研讨会和两次讲习班。

项目成果

O.MATSUSHITA: "Substrate recognition by the collagen-binding domain of clostridium histolyticum class I collagenase."J.Biol.Chem.. 276(12). 8761-8770 (2001)

O.MATSUSHITA：“溶组织梭菌 I 类胶原酶的胶原蛋白结合结构域对底物的识别。”J.Biol.Chem.. 276(12)。

M. TANABE: "The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative splicing"J. Biol. Chem.. 274(39). 27845-27856 (1999)

M. TANABE：“哺乳动物 HSF4 基因通过选择性剪接产生热休克基因的激活子和阻遏子”J.

Y. KAWAZOE: "HSF3 is a major heat shock responsive factor during chicken embryonic development"Eur. J. Biochem.. 265(2). 688-697 (1999)

Y. KAWAZOE：“HSF3 是鸡胚胎发育过程中的主要热休克反应因子”Eur。

K.Terada, M.MORI: "The human DanJ homologue dj2 facilitates mitochondrial protein import and luciferase refolding." J.Cell Biol.139. 1089-1095 (1997)

K.Terada、M.MORI：“人类 DanJ 同源物 dj2 促进线粒体蛋白输入和荧光素酶重折叠。”

永田和宏, 森正敬, 吉田賢右: "分子シャペロンによる細胞機能制御"シュプリンガー・フェアラーク東京. 219 (2001)

Kazuhiro Nagata、Masataka Mori、Kensuke Yoshida：“分子伴侣控制细胞功能”Springer-Verlag 东京 219 (2001)。