Providing Silicone with Bioactivity by treatment with Hydrogenperoxide containing Metal Chlorides

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Silicone elastomer was chemically treated at 60℃ for 7 days with 30 wt% HィイD22ィエD2OィイD22ィエD2 solutions with or without TaClィイD25ィエD2 and soaked for various periods in a simulated body fluid (Kokubo solution) up to 21 days. Apatite formation ability of the surface of the silicone elastomer specimens was investigated with thin-film X-ray diffraction and FT-IR reflection spectroscopy. These silicone specimens did not deposit apatite or calcium phosphates, irrespective of chemical treatment. Osteoblast-like cells (MC3T3-E1) derived from mouse were cultured on the specimens at 36.5℃ under 5%COィイD22ィエD2 and 95% humidity. Similar degree of proliferation of cells was observed at 7 days among three specimens, while the no treatment specimen after incubation for 5 days showed a lower degree of proliferation than the silicone treated with 30 wt% HィイD22ィエD2OィイD22ィエD2 solutions with or without TaClィイD25ィエD2. Alkaline phosphatase activity of the cells proliferated on the no treatment specimen was lower than those of the silicone treated with 30 wt% HィイD22ィエD2OィイD22ィエD2 solutions with or without TaClィイD25ィエD2. These results indicate that the cytocompatibility of the silicone could be improved by the chemical treatment with 30 wt% HィイD22ィエD2OィイD22ィエD2 solutions with or without TaClィイD25ィエD2.