Providing Titanium with Bioactivity by the Use of Low-melting Glass

利用低熔点玻璃赋予钛生物活性

基本信息

  • 批准号:
    07558127
  • 负责人:
  • 金额:
    $ 4.29万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 财政年份:
    1995
  • 资助国家:
    日本
  • 起止时间:
    1995 至 1996
  • 项目状态:
    已结题

项目摘要

Titanium is only biocompatible and has no ability to bond to bone though it is widely used in clinical field as one of the important bone-implant. It is thus needed to provide it with bioactivity. In the present project enameling bioactive glass has been successfully attempted.1. Exploiting bioactive glasses(1) CaO-B_2O_3-SiO_2Apatite formation on the glasses in this system were examined by soaking them in a simulated body fluid (SBF), known as Kokubo solution. Almost all the glasses exhibited bioactivity or deposited apatite though too much content of boron oxide depressed the bioactivity.(2) Na_2O-B_2O_3-SiO_2Bioactivity was also examined for the sodium borosilicate glasses and was correlated to the local environment of Si. ^<29>Si MAS NMR spectra showed that the glasses around a composition 30Na_2O・20B_2O_3・50SiO_2 was very bioactive because about 80% Si atoms had two bridging oxygen atoms.2. Bioactivity of glass-coated Ti(1) CaO-B_2O_3-SiO_2A glass of composition 45CaO・30SiO_2・25B_2O_3 was selected for enameling Ti since it was one of the most bioactive glasses and had a thermal expansion coefficient most similar to that of Ti. The glass-coated Ti deposited apative within about 12 hours when soaked in SBF.(2) Na_2O-B_2O_3-SiO_2Ti specimen coated with a sodium borosilicate glass of composition 35.9SiO_2・21.1Na_2O・38B_2O_3・5CaO exhibited bioactivity in 7 days.
钛作为一种重要的骨植入材料在临床上得到了广泛的应用,但它仅具有生物相容性,不具有与骨结合的能力。因此,需要为其提供生物活性。在本项目中,搪瓷生物活性玻璃已成功研制成功.生物活性玻璃的开发(1)将该系统中的玻璃浸入模拟体液(SBF)(称为Kokubo溶液)中,观察其上CaO-B_2 O_3-SiO_2磷灰石的形成。几乎所有的玻璃都显示出生物活性或沉积磷灰石,但过多的氧化硼含量会降低玻璃的生物活性。(2)还考察了钠硼硅玻璃的Na_2 O-B_2 O_3-SiO_2生物活性,并与Si的局部环境相关。~ 13 <29>Si MAS NMR谱表明,组成为30Na_2O·20B_2O_3·50SiO_2的玻璃具有很好的生物活性,这是因为约80%的Si原子具有两个桥联氧原子.玻璃包覆Ti(1)CaO-B_2 O_3-SiO_2玻璃的生物活性选择成分为45 CaO·30SiO_2·25B_2O_3的玻璃用于钛的搪瓷,因为它是最具生物活性的玻璃之一,并且具有与钛最相似的热膨胀系数。当浸泡在SBF中时,玻璃涂覆的Ti在约12小时内沉积。(2)Na_2 O-B_2 O_3-SiO_2Ti涂层玻璃(成分为35.9SiO_2·21.1Na_2O·38B_2O_3·5CaO)在7天内显示出生物活性。

项目成果

期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
A.Osaka: "Bioactivity of Alkali and Alkaline Earth Borosilicate Glasses" Proceedings of the Second International Conference on Borate Glasses, Crystals & Melts. (in press).
A.Osaka:“碱金属和碱土金属硼硅酸盐玻璃的生物活性”第二届国际硼酸盐玻璃、晶体会议论文集
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
A.Osaka: "Bioactive Calcium Borosilicate Glasses for Enameling Titanium" Memoirs of the Faculty of Engineering, Okayama Unversity. 31 [2] (in press). (1997)
A.Osaka:“用于搪瓷钛的生物活性钙硼硅酸盐玻璃”冈山大学工学院回忆录。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
A.Osaka: "Bioactivity of Alkali and Alkaline Earth Borosilicate Glasses" Proceedings of the Second International Conference on Borate Glasses,Crystals & Melts. (印刷中).
A. 大阪:“碱金属和碱土金属硼硅酸盐玻璃的生物活性”第二届硼酸盐玻璃、晶体和熔体国际会议论文集(正在出版)。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
A.Osaka: "Bioactive Calcium Borosilicate Glases for Enameling Titanium" Memoirs of the Faculty of Engineering,Okayama University. 31巻2号(印刷中). (1997)
A.Osaka:“用于搪瓷钛的生物活性钙硼硅酸盐玻璃”冈山大学工程学院回忆录第 31 卷,第 2 期(出版中)。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
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HAYAKAWA Satoshi其他文献

HAYAKAWA Satoshi的其他文献

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{{ truncateString('HAYAKAWA Satoshi', 18)}}的其他基金

Molecular backgrounds of transplacental Zika fever infection.
经胎盘寨卡热感染的分子背景。
  • 批准号:
    17H04341
  • 财政年份:
    2017
  • 资助金额:
    $ 4.29万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Analysis of placental barrier functions for intra uterine viral infections
子宫内病毒感染的胎盘屏障功能分析
  • 批准号:
    24390382
  • 财政年份:
    2012
  • 资助金额:
    $ 4.29万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Therapeutic potentials of parasitic antigens on a murine recurrent spontaneous abortion
寄生虫抗原对小鼠复发性流产的治疗潜力
  • 批准号:
    21592114
  • 财政年份:
    2009
  • 资助金额:
    $ 4.29万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Preparation of nanometer-scale rod array and biomedical application
纳米级棒状阵列的制备及其生物医学应用
  • 批准号:
    19360301
  • 财政年份:
    2007
  • 资助金额:
    $ 4.29万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Role of local decidual large granular luphocytes and local immune responses on materno-fetal HIV transmission
局部蜕膜大颗粒红细胞和局部免疫反应在母婴 HIV 传播中的作用
  • 批准号:
    17390454
  • 财政年份:
    2005
  • 资助金额:
    $ 4.29万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Preparation of self-organized nano-structured apatite and the protein adsorption property
自组织纳米结构磷灰石的制备及其蛋白质吸附性能
  • 批准号:
    16360330
  • 财政年份:
    2004
  • 资助金额:
    $ 4.29万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Clinical-immunological analysis of vertical HIV transmission employing a monkey model
采用猴模型进行 HIV 垂直传播的临床免疫学分析
  • 批准号:
    15591782
  • 财政年份:
    2003
  • 资助金额:
    $ 4.29万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
CD4 independent vertical HIV transmission and possible involvement of decidual immune cells
CD4 独立的 HIV 垂直传播和蜕膜免疫细胞的可能参与
  • 批准号:
    12671634
  • 财政年份:
    2000
  • 资助金额:
    $ 4.29万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Analysis of trans-placental HIV infection
经胎盘HIV感染分析
  • 批准号:
    10671572
  • 财政年份:
    1998
  • 资助金额:
    $ 4.29万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Providing titanium for Bone Substitution with Bioactivity by treatment with Hydrogenperoxide containing Metal Chlorides
通过含有金属氯化物的过氧化氢处理,为骨替代提供具有生物活性的钛
  • 批准号:
    09558120
  • 财政年份:
    1997
  • 资助金额:
    $ 4.29万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)

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