Therapeutic potentials of parasitic antigens on a murine recurrent spontaneous abortion

寄生虫抗原对小鼠复发性流产的治疗潜力

• 批准号: 21592114
• 负责人: HAYAKAWA Satoshi
• 金额: $ 1.75万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21592114/
• 关键词: 習慣流産; 免疫機序; 寄生虫抗原; Th17; 寄生虫; 免疫調節; 衛生仮説; マウスモデル

The mammalian fetuses are semi-allograft for mothers. Therefore the failure of immunological tolerance often causes pregnancy loss. We revealed therapeutic potential of the recombinant antigen from a nematoda parasite, Dirofilaria immitis rDiAg with a murine recurrent spontaneous abortion model.(CBA/J×DBA/2J) The rDiAg treatment significantly reduced the resorption rates of mouse model, which mimic human pregnancy failures with allo-immune backgrounds.Serum IL-4, IL-23 and TNF-α concentrations were significantly lower in rDiAg-treated mice than mock-treated mice. The serum IL-17 level was also reduced in rDiAg-treated mice but the difference was not significant. Our observations suggest as the first time of therapeutic potentials of parasites for pregnancy loss.

哺乳动物胎儿是母体的半同种异体移植物。因此，免疫耐受的失败往往会导致妊娠失败。我们揭示了从寄生虫，犬恶丝虫rDiAg与小鼠复发性自然流产模型的重组抗原的治疗潜力。(CBA/J×DBA/2 J）rDiAg治疗组小鼠血清IL-4、IL-23和TNF-α浓度显著低于假治疗组，而rDiAg治疗组小鼠血清IL-4、IL-23和TNF-α浓度显著低于假治疗组。rDiAg处理的小鼠血清IL-17水平也降低，但差异不显著。我们的观察首次表明寄生虫对妊娠丢失的治疗潜力。

项目成果

【生殖器の感染防御機構】女性生殖器における感染防御機構オーバービュー

[生殖器官感染防御机制] 女性生殖器官感染防御机制概述

• 发表时间: 2009
• 期刊: HORMONE FRONTIER INGYNECOLOGY (1340-220X) 16巻4号
• 作者: Trinh QD,Pham NT;Lam BQ;Le TP;Truong KH;Le TQ;Vo HT;Tang TC;Ha TM;Izumi Y;Mizuguchi M;Hayakawa S;Ushijima H;早川智
• 通讯作者: 早川智

CBA/J×DBA/2J流産マウスモデルにおける"当帰芍薬散""柴苓湯"の効果

“时尺药散”和“Saireito”对CBA/J×DBA/2J流产小鼠模型的影响

• 发表时间: 2011
• 作者: 相澤(小峯)志保子;早川智
• 通讯作者: 早川智

今日の治療指針(山口徹他編)

今日治疗指南（山口彻等编辑）

• 发表时间: 2011
• 作者: Hayashi M;Chernov M;Tamura N;Nagai M;Yomo S;Ochiai T;Amano K;Izawa M;Hori T;Muragaki Y;Iseki H;Okada Y;Takakura K.;早川智 (分担執筆)
• 通讯作者: 早川智 (分担執筆)

The therapeutic potential of the recombinant antigen from Dirofilaria immitis(rDiAg) for immune mediated pregnancy loss

恶丝虫重组抗原（rDiAg）对免疫介导的流产的治疗潜力

• 发表时间: 2010
• 作者: Shihoko Komine-Aizawa;Yasuyuki Izumi;and Satoshi Hayakawa
• 通讯作者: and Satoshi Hayakawa

The therapeutic potential of the recombinant antigen from Dirofilaria immitis(rDiAg) for immune-mediated pregnancy loss

恶丝虫重组抗原（rDiAg）对免疫介导性流产的治疗潜力

• 发表时间: 2011
• 期刊: J Reprod Immunol
• 影响因子: 3.4
• 作者: Komine-Aizawa S;Izumi Y;Imai S;Fujita K;Hayakawa S
• 通讯作者: Hayakawa S