Therapeutic potentials of parasitic antigens on a murine recurrent spontaneous abortion

哺乳动物胎儿是母亲的半同种异体移植。因此，免疫耐受的失败往往导致妊娠丢失。我们发现了来自线虫寄生虫的重组抗原在小鼠复发性自然流产模型中的治疗潜力。（CBA/J×DBA/2J） rDiAg治疗可显著降低小鼠模型的吸收率，该模型模拟了具有同种免疫背景的人类妊娠失败。rdiag处理小鼠血清IL-4、IL-23和TNF-α浓度显著低于模拟处理小鼠。rdiag处理的小鼠血清IL-17水平也有所降低，但差异不显著。我们的观察结果首次提示了寄生虫对妊娠丢失的治疗潜力。

The mammalian fetuses are semi-allograft for mothers. Therefore the failure of immunological tolerance often causes pregnancy loss. We revealed therapeutic potential of the recombinant antigen from a nematoda parasite, Dirofilaria immitis rDiAg with a murine recurrent spontaneous abortion model.(CBA/J×DBA/2J) The rDiAg treatment significantly reduced the resorption rates of mouse model, which mimic human pregnancy failures with allo-immune backgrounds.Serum IL-4, IL-23 and TNF-α concentrations were significantly lower in rDiAg-treated mice than mock-treated mice. The serum IL-17 level was also reduced in rDiAg-treated mice but the difference was not significant. Our observations suggest as the first time of therapeutic potentials of parasites for pregnancy loss.