Induction Mechanisms by Prolaction of Mammary Tumor, Uterine Adenomyosis and Pancreatic Hyperplasia in Mice

小鼠乳腺肿瘤、子宫腺肌病和胰腺增生的诱发机制

• 批准号: 60540478
• 负责人: MORI Takao
• 金额: $ 1.09万
• 依托单位: University of Tokyo, Faculty of Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60540478/
• 关键词: Mouse; Hyperprolactinemia; Mammary tumor; Uterine adenomyosis; pancreatic tumor; 細胞分裂

Prolactin is a versatile hormone in its physiological effects on vertebrates. However, it is also well recognized that prolactin induces an abnormal proliferation of the several organs in cooperation with the other hormones. Namely, prolactin causes to elevate the mammary gland DNA sysnthesis in mice. Acceleration of the mammary DNA synthesis is a limiting factor of the tumorigenesis. In uterus, experimentally-induced hyperprolactinemia results in an early and high incidence of the adenomyosis. The primary cause of development of adenomyosis is a disintegration of the uterine myometrium associated with proliferation of endometrial tissues. Furthermore, hyperprolactinemia also induces a marked proliferation of both endocrine and exocrine pancreatic tissues, and then results in teh hyperplastic lesions. All results indicate that the high circulating levels of prolactin may be responsible for the occurrence of abnormal proliferation of some target tissues, suggesting the participation of prolactin in the genesis of lesions and tumors.

催乳素是一种对脊椎动物具有多种生理作用的激素。然而，人们也认识到，催乳素与其他激素一起诱导几个器官的异常增殖。即催乳素引起小鼠乳腺DNA合成增加。乳腺DNA合成的加速是肿瘤发生的限制因素。在子宫内，实验诱导的高泌乳素血症导致子宫腺肌病的早期和高发病率。子宫腺肌病的主要原因是子宫肌层的崩解和子宫内膜组织的增生。此外，高催乳素血症还可引起胰腺内分泌和外分泌组织的显著增生，从而导致增生性病变。结果提示，高循环水平的催乳素可能是导致某些靶组织异常增殖的原因，提示催乳素参与了病变和肿瘤的发生。

项目成果

守隆夫: 実験医学. 4巻5号. 445-446 (1986)

森隆夫：实验医学，第 4 卷，第 5 期。445-446 (1986)

T.Mori: Acta Histochemistry and Cytochemistry. 19. 421-428 (1986)

T.Mori：组织化学和细胞化学学报。

T. Mori: "Induction mechanisms by prolactin of mammary tumor, uterine adenomyosis and pancreatic tumor in SHN mice" Laboratory Animals and Animal Experiments. 4. 16-20 (1987)

T. Mori：“催乳素对 SHN 小鼠乳腺肿瘤、子宫腺肌症和胰腺肿瘤的诱导机制”实验动物和动物实验。

守隆夫: ラボラトリーアニマル. 4. 16-20 (1987)

森隆雄：实验动物。4. 16-20 (1987)

T.Mori: Kyoto Prolactin Conference. vol.1. 145-153 (1986)

T.Mori：京都催乳素会议。