Species and phylogenical diferences for the immunohistological properties of lymphoid postcapillary venules of some mammals

一些哺乳动物淋巴毛细血管后微静脉免疫组织学特性的物种和系统发育差异

• 批准号: 60580034
• 负责人: KIMURA Michio
• 金额: $ 0.83万
• 依托单位: Kansai college of Acupuncture Medicine (1986)Toyama Medical and Pharmaceutical University (1985)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1986
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60580034/
• 关键词: Postcapillary venule; suncus; NOD mouse; pancreatic lymph node; ヌードマウスPCV

Postcapillary venules (PCV) of mammalian lymphoid tissues have been regarded as a specialized type of venule representing sites of lymphocyte migration from blood to lymphoid parenchyma. Recent our investigations (M. Kimura Immunology 49:223-229 1983; M. Kimura and K. Takaya J. Electron Microsc. 33:123-130 1984) have suggested that the selective homing of lymphocytes is determined by a specific lymphocyte interaction with localized antigen in the individual lymphoid organ and is controlled at a level of interaction between the lymphocytes and the endothelial cells, in particular the PCV endothelium of the various mammalian lymphoid tissues. In the present research project, it was to examine the immunohistological properties of some mammalian PCVs using light and electron microscopies. An interesting finding of newly forming-PCV could be obsereved in the pathological lymphocyte infiltrating region of NOD mouse pancreatic islets (K. Tohya, K. Kuroiwa, R. Sugata and M. Kimura Proc. XIth Int. Cong. Electron Microscopy 1986).

哺乳动物淋巴组织的毛细血管后静脉（PCV）被认为是一种专门的静脉，代表了从血液到淋巴地实质的淋巴细胞迁移的部位。我们最近的研究（M. Kimura免疫学49：223-229 1983; M. Kimura和K. Takaya J. ElectronMicros。33：123-130 1984）表明，淋巴细胞的选择性归巢是由与局部抗原在lymphiet and Interced and semphie and Inessation的特定淋巴细胞相互作用确定的淋巴细胞的选择性归共菌，并在lymphociet and semphiped ant s rymphiped and semphiped and Interc.内皮细胞，特别是各种哺乳动物淋巴组织的PCV内皮。在本研究项目中，它是使用光和电子显微镜检查一些哺乳动物PCV的免疫组织学特性。可以在NOD小鼠胰岛的病理淋巴细胞浸润区域中观察到新形成的PCV的一个有趣发现（K. Tohya，K。Kuroiwa，R。Sugata和M. Kimura和M. KimuraProc。XithInt。XithInt。Cong。

项目成果

M. Kimura, K. Kuroiwa, K. Tohya and R. Sugata: "Ultrastructure of endoneurial mast cell in the peripheral nervous system of the suncus" Proc. XIth Cong. on Electron Microscopy. 3127-3128 (1986)

M. Kimura、K. Kuroiwa、K. Tohya 和 R. Sugata：“太阳周围神经系统中神经内膜肥大细胞的超微结构”Proc。

M. Kimura: "Glomerular HRP-antibody accumulation in ddY mice by an enteric HRP-administration : An immunoelctron microscopic study" Proc. XIth Cong. on Electron Microscopy. 2939-2340 (1986)

M. Kimura：“通过肠道 HRP 给药在 ddY 小鼠中肾小球 HRP 抗体积累：一项免疫电子显微镜研究”Proc。

H.Nishino;T.Ono;J.Takahashi;M.Kimura;S.Shiosaka;M.Tohyama: Neuroscience Letter. 64. 184-190 (1986)

H.Nishino；T.Ono；J.Takahashi；M.Kimura；S.Shiosaka；M.Tohyama：神经科学快报。

M.Kimura: Proc.XIth Int.Cong.on Electron Microscopy. 2939-2340 (1986)

M.Kimura：Proc.XIth Int.Cong.on 电子显微镜。

M.Kimura;T.Toyomasu;N.Ikegami;T.Matsubucchi;H.Kawagoe;M.Hirata: J.Clin.Electron Microscopy. (1986)

M.Kimura;T.Toyomasu;N.Ikegami;T.Matsubucchi;H.Kawagoe;M.Hirata：J.Clin.电子显微镜。