Species and phylogenical diferences for the immunohistological properties of lymphoid postcapillary venules of some mammals

一些哺乳动物淋巴毛细血管后微静脉免疫组织学特性的物种和系统发育差异

• 批准号: 60580034
• 负责人: KIMURA Michio
• 金额: $ 0.83万
• 依托单位: Kansai college of Acupuncture Medicine (1986)Toyama Medical and Pharmaceutical University (1985)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1986
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60580034/
• 关键词: Postcapillary venule; suncus; NOD mouse; pancreatic lymph node; ヌードマウスPCV

Postcapillary venules (PCV) of mammalian lymphoid tissues have been regarded as a specialized type of venule representing sites of lymphocyte migration from blood to lymphoid parenchyma. Recent our investigations (M. Kimura Immunology 49:223-229 1983; M. Kimura and K. Takaya J. Electron Microsc. 33:123-130 1984) have suggested that the selective homing of lymphocytes is determined by a specific lymphocyte interaction with localized antigen in the individual lymphoid organ and is controlled at a level of interaction between the lymphocytes and the endothelial cells, in particular the PCV endothelium of the various mammalian lymphoid tissues. In the present research project, it was to examine the immunohistological properties of some mammalian PCVs using light and electron microscopies. An interesting finding of newly forming-PCV could be obsereved in the pathological lymphocyte infiltrating region of NOD mouse pancreatic islets (K. Tohya, K. Kuroiwa, R. Sugata and M. Kimura Proc. XIth Int. Cong. Electron Microscopy 1986).

哺乳动物淋巴组织的毛细血管后小静脉（PCV）被认为是一种特殊类型的小静脉，代表淋巴细胞从血液迁移到淋巴实质的位置。我们最近的研究（M. Kimura Immunology 49:223-229 1983； M. Kimura and K. Takaya J. Electron Microsc. 33:13 3-130 1984）表明，淋巴细胞的选择性归巢是由淋巴细胞与单个淋巴器官中局部抗原的特异性相互作用决定的，并在淋巴细胞与内皮细胞，特别是各种哺乳动物淋巴组织的PCV内皮之间的相互作用水平上受到控制。本研究利用光镜和电镜观察了部分哺乳动物pcv的免疫组织学特征。在NOD小鼠胰岛病理性淋巴细胞浸润区可以观察到新形成的pcv （K. Tohya， K. Kuroiwa， R. Sugata and M. Kimura等）的有趣发现。电子显微镜1986)。

项目成果

M. Kimura, K. Kuroiwa, K. Tohya and R. Sugata: "Ultrastructure of endoneurial mast cell in the peripheral nervous system of the suncus" Proc. XIth Cong. on Electron Microscopy. 3127-3128 (1986)

M. Kimura、K. Kuroiwa、K. Tohya 和 R. Sugata：“太阳周围神经系统中神经内膜肥大细胞的超微结构”Proc。

M. Kimura: "Glomerular HRP-antibody accumulation in ddY mice by an enteric HRP-administration : An immunoelctron microscopic study" Proc. XIth Cong. on Electron Microscopy. 2939-2340 (1986)

M. Kimura：“通过肠道 HRP 给药在 ddY 小鼠中肾小球 HRP 抗体积累：一项免疫电子显微镜研究”Proc。

M.Kimura: Proc.XIth Int.Cong.on Electron Microscopy. 2939-2340 (1986)

M.Kimura：Proc.XIth Int.Cong.on 电子显微镜。

H.Nishino;T.Ono;J.Takahashi;M.Kimura;S.Shiosaka;M.Tohyama: Neuroscience Letter. 64. 184-190 (1986)

H.Nishino；T.Ono；J.Takahashi；M.Kimura；S.Shiosaka；M.Tohyama：神经科学快报。

M.Kimura;T.Toyomasu;N.Ikegami;T.Matsubucchi;H.Kawagoe;M.Hirata: J.Clin.Electron Microscopy. (1986)

M.Kimura;T.Toyomasu;N.Ikegami;T.Matsubucchi;H.Kawagoe;M.Hirata：J.Clin.电子显微镜。