Immunohistological evaluation of pathogenetic models of IgA nephritis in ddY mice

高龄雌性小鼠肾小球igA沉积强烈，作为人类igA肾炎的有效模型引起了许多研究者的关注。本实验研究了Peyer’s patch hrp注射液和静脉注射印度墨水后小鼠igA肾炎的免疫组织学发病机制。采用注射墨水人工阻断肝网状内皮吞噬（REP）功能。目前的HRP和墨水注射主要导致典型的HRP抗体沉积在肾小球系膜下区域。高倍镜下沉积物常显示指状或条纹状结构，如先前在人igA肾炎中所见。免疫组织学检查显示，小鼠血清酶标抗体沉积区与对照序列切片中igA积累区一致。这些数据可能表明，在igA肾炎的持续诱导中，REP功能的重要参与与肠道相关的igA免疫有关。

Aged femal ddy mice, rerely revealed intense glomerular igA depositions, have att-racted the attention of many investigators as a useful model of human igA nephritis. The present experiments have examined an immunohistological pathogenesis of the igA nephritis induced by Peyer's patch HRP-injection and following intravenous indian ink-injection in the mice. The ink-injection was employed for the artificial block-ing of liver reticulo-endothelial phagocytotic (REP) function. The present HRP and ink-injections resulted mostly a typical depositoin of HRP-antibody in the glomeru-lar submesangial regions. High magnification of the depostion indicated often finger or striple-like structures, described previously in a human igA nephritis. The immunohistological examination of ddy mice revealed that the HRP-antibody deposit-area coincides with the igA accumulated areas in their contrast serial sections. These data probably indicate that an essential participation of REP function in the constant induction of igA nephritis, in relation with the gut-associated igA immunity.