Analysis of neuro oncogenesis by genetically different susceptible strains of rats.

遗传不同易感品系大鼠的神经肿瘤发生分析。

• 批准号: 61570175
• 负责人: ITO Akihiro
• 金额: $ 1.41万
• 依托单位: HIROSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-61570175/
• 关键词: 乳癌; 腎腫瘍; ラット; 系統差; MNU; MNNG; 胃癌; 肺腫瘍

This study was primarily aimed to investigate the Ethyl-nitrosourea (ENU)induced neuro-oncogenesis in the different strains of rats.By the administration of ENUinto newborn rats, almost 100% of brain cortical tumors, trigeminal nerve tumors could be induced.Similar agents, methylnitrosourea (MNU) could also induce tumors at nervous systems, but also kidney and mammary tumors as well. Occurrence of kidney and mammary tumors has been unique, in which kidney tumor seemed to be regulated by recessive trait, but mammary tumors occur by the Mendel's law.The study has been extended to analyze the genetical background in more details.

本实验主要研究乙基亚硝基脲（Ethyl-nitrosourea，ENU）对不同品系大鼠神经系统肿瘤的诱发作用，结果表明，ENU可诱发100%的脑皮质肿瘤和三叉神经肿瘤，甲基亚硝基脲（methylnitrosourea，MNU）也可诱发神经系统肿瘤，但对肾脏和乳腺肿瘤也有诱发作用。肾脏肿瘤和乳腺肿瘤的发生具有独特性，其中肾脏肿瘤的发生受隐性遗传的调控，而乳腺肿瘤的发生受孟德尔遗传规律的调控，本文对肾脏肿瘤和乳腺肿瘤的遗传背景进行了详细的分析。

项目成果

伊藤明弘: Cancer Research. 45. 6436-6441 (1985)

伊藤昭宏：癌症研究 45。6436-6441 (1985)。

Naito, N., Naito, Y., and DiGiovanni, J.: "Comparison of the histological changes in the skin of DBA/2 and C57BL/6mice following expoure to various promoting agents." Carcinogenesis. 8. 1807-1815 (1987)

Naito, N.、Naito, Y. 和 DiGiovanni, J.：“DBA/2 和 C57BL/6 小鼠暴露于各种促进剂后皮肤组织学变化的比较。”

Naito, M., Chenicek, K.J., Naito, Y. and Digiovanni, J.: "Susceptibility to pherbol ester skin tumor promotion in (C57BL/6 x DBA/2)F_1 mice is inherited as an incomplete dominant trait; Evidence for multi-locus involvement." Carcinogenesis. 9. (1988)

Naito, M.、Chenicek, K.J.、Naito, Y. 和 Digiovanni, J.：“(C57BL/6 x DBA/2)F_1 小鼠对佛醇酯皮肤肿瘤促进的易感性是作为不完全显性性状遗传的；多种证据