Analysis of neuro oncogenesis by genetically different susceptible strains of rats.
Analysis of neuro oncogenesis by genetically different susceptible strains of rats.
遗传不同易感品系大鼠的神经肿瘤发生分析。
批准号：
61570175
负责人：
ITO Akihiro
金额：
$1.41万
依托单位：
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1986
资助国家：
日本
项目状态：
已结题
起止时间：
1986 至 1987
中文摘要
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英文摘要
This study was primarily aimed to investigate the Ethyl-nitrosourea (ENU)induced neuro-oncogenesis in the different strains of rats.By the administration of ENUinto newborn rats, almost 100% of brain cortical tumors, trigeminal nerve tumors could be induced.Similar agents, methylnitrosourea (MNU) could also induce tumors at nervous systems, but also kidney and mammary tumors as well. Occurrence of kidney and mammary tumors has been unique, in which kidney tumor seemed to be regulated by recessive trait, but mammary tumors occur by the Mendel's law.The study has been extended to analyze the genetical background in more details.
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会议论文
伊藤明弘: Cancer Research. 45. 6436-6441 (1985)
伊藤昭宏：癌症研究 45。6436-6441 (1985)。
伊藤昭宏：癌症研究 45。6436-6441 (1985)。
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Naito, N., Naito, Y., and DiGiovanni, J.: "Comparison of the histological changes in the skin of DBA/2 and C57BL/6mice following expoure to various promoting agents." Carcinogenesis. 8. 1807-1815 (1987)
Naito, N.、Naito, Y. 和 DiGiovanni, J.：“DBA/2 和 C57BL/6 小鼠暴露于各种促进剂后皮肤组织学变化的比较。”
Naito, N.、Naito, Y. 和 DiGiovanni, J.：“DBA/2 和 C57BL/6 小鼠暴露于各种促进剂后皮肤组织学变化的比较。”
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Naito, M., Chenicek, K.J., Naito, Y. and Digiovanni, J.: "Susceptibility to pherbol ester skin tumor promotion in (C57BL/6 x DBA/2)F_1 mice is inherited as an incomplete dominant trait; Evidence for multi-locus involvement." Carcinogenesis. 9. (1988)
Naito, M.、Chenicek, K.J.、Naito, Y. 和 Digiovanni, J.：“(C57BL/6 x DBA/2)F_1 小鼠对佛醇酯皮肤肿瘤促进的易感性是作为不完全显性性状遗传的；多种证据
Naito, M.、Chenicek, K.J.、Naito, Y. 和 Digiovanni, J.：“(C57BL/6 x DBA/2)F_1 小鼠对佛醇酯皮肤肿瘤促进的易感性是作为不完全显性性状遗传的；多种证据
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Changes in distribution industry by ICT
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依托单位：
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依托单位：
Effect of tritium on embryo and fetuses in rodents
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依托单位：
海外基金
