Fate of metallic mercury in the body.

金属汞在体内的命运。

• 批准号: 62570247
• 负责人: OGATA Masana
• 金额: $ 0.83万
• 依托单位: Department of Public Health, Okayama University, Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1987
• 资助国家: 日本
• 起止时间: 1987 至 1988
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-62570247/
• 关键词: Arterial blood; Metallic mercury; Fetus; Acatalasemic mice; Exhaled air; 動脈血; 暴露条件

In order to know the effect of catalase on the distribution and excretion of the mice exposed to matellic mercury, following experiments were performed.1. Concentration of metallic mercury in an arterial blood of acatalasemic mice (A) exposed to metallic mercury was higher then that of normal (N), but concentration of mercuric ion in the arterial blood was vice vera.2. Amounts of mercury exhaled from mice exposed to metallic mercury were in proportional with mercury concentration exposed mice.3. Both mice of A and N were injected with ethanol (E) or aminotriazole (AT) followed by being exposed to metallic mercury. The amount of mercury exhaled from mice is descending order of A-AT>N-AT>A-ET>N-ET>A>N. Concentration of mercury in kidneys and urine of N-ET was higher than that in N, respectively.4. The ratio of mercury concentration in fetus to that in blood of pregnant mice exposed to metallic mercury was in the descending order of A-AT>N-AT>A>N.

为了解过氧化氢酶对金属汞暴露小鼠体内分布和排泄的影响，进行了以下实验。结论：1.暴露于金属汞的贫血小鼠(A)动脉血中金属汞浓度高于正常对照组(N)，而动脉血汞离子浓度低于正常对照组(N)。暴露于金属汞的小鼠呼出的汞的量与暴露小鼠的汞浓度成正比。A组和N组小鼠均注射乙醇(E)或氨基三氮唑(AT)，然后暴露于金属汞。小鼠排出汞的量由大到小依次为A-AT&GT；N-AT&GT；A-ET&GT；N-ET&GT；A&GT；N-ET的肾脏和尿汞浓度分别高于N-ET。金属汞暴露孕鼠胎血汞浓度比值由大到小依次为A-AT&GT；N-AT&GT；A&GT；N。

项目成果

Masana Ogata,;Akira Matsuda,;Tadamichi Meguro,;Hiromi Aikoh.: Physiological Chemistry and Physics. 19. 79-82 (1987)

Masana Ogata,;Akira Matsuda,;Tadamichi Meguro,;Hiromi Aikoh.：生理化学和物理学。

Masana Ogata,;Tadamichi Meguro.: Physiological Chemistry and Physics and Medical NMR.18. 165-170 (1987)

Masana Ogata，;Tadamichi Meguro.：生理化学和物理以及医学 NMR.18。

Tadamichi Meguro: "Effect of aminotriazole on mercury uptake by the fetus of normal and acatalasemic mice exposed to metallic mercury." Acta Medica Okayama. 41. 243-248 (1987)

Tadamichi Meguro：“氨基三唑对接触金属汞的正常小鼠和去贫血小鼠胎儿吸收汞的影响。”