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Comparison between organic solvents in the urine of workers exposed to organic solvents and their solvent's metabolites

接触有机溶剂工人尿液中有机溶剂及其代谢物的比较

基本信息

批准号：
05670372
负责人：
OGATA Masana
金额：
$ 1.15万
依托单位：
Kawasaki University of Medical Welfare
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1994
项目状态：
已结题

项目摘要

The method for preservation of urinary solvents of low concentration was examined and a new method was established. In the new method, the vials were filled with urine receiving beta cyclodextrin beforehand and sealed with aluminium seals.Workers were exposed to a mixed solvent of toluene, methylethylketone and isopropanol, or that of toluene, xylene and methyl ethyl ketone, or that of dichloromethane, 1,2-dichloroethane and trichloroethylene, and each solvent to which workers were simultaneously exposed and parent solvents or metabolites in the urine of workers exposed to the mixed solvents were measured.A close correlation was present between the ambient concentration of each solvent and the urinary concentration of the same solvent in the urine of workers showed a higher value than that between the ambient concentration and the solvent concentration corrected by creatinine concentration or by specific gravity. In contrast to this, the correlation coefficient between the ambient concentration of solvents and the corrected concentraion of metabolies by creatinine concentration or by specific gravity in the urine was higher than that between the ambient concentration and uncorrected concentration of metabolites. These results are explained by assuming that solvent is transferred from blood to urine by simple diffusion. Therefore, the correlation coefficient between the uncorrected concentration of urinary solvents and the metabolite concentrations corrected by creatinine or by specific gravity was higher than that between the uncorrected concentration of urinary solvents and uncorrected concentration of metabolite concentrations.

对低浓度尿液溶剂的保存方法进行了探讨，建立了新的方法。在新方法中，预先将接受β环糊精的尿液装满小瓶，并用铝密封件密封。工作人员暴露在甲苯、甲乙酮和异丙醇的混合溶剂中，或甲苯、二甲苯和甲乙酮的混合溶剂中，或二氯甲烷、1,2-二氯乙烷和三氯乙烯的混合溶剂中，每种溶剂都接触到了不同的溶剂。各溶剂的环境浓度与工人尿液中相同溶剂的尿浓度之间存在密切的相关性，其值高于环境浓度与经肌酐浓度或比重校正的溶剂浓度之间的相关性。与此相反，环境溶剂浓度与肌酐浓度或尿液比重校正的代谢浓度之间的相关系数高于环境浓度与未校正的代谢物浓度之间的相关系数。这些结果是通过假设溶剂通过简单扩散从血液转移到尿液来解释的。因此，尿溶剂的未校正浓度与肌酐或比重校正的代谢物浓度之间的相关系数高于尿溶剂的未校正浓度与代谢物浓度的未校正浓度之间的相关系数。