Relationship of levels of personal exposure with ambient concentrations and levels of biological determinants in workers exposed to organic solvents

个人接触水平与环境浓度以及接触有机溶剂的工人的生物决定因素水平的关系

• 批准号: 07670469
• 负责人: OGATA Masana
• 金额: $ 1.22万
• 依托单位: Kawasaki University of Medical Welfare
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07670469/
• 关键词: Biological monitoring; Organic solvent; Urinary solvent; Urinary metabolite; Breath zone air; Mixed solvent; hippuric acid.; Head space gas; 環境濃度; 個人暴露濃度; トルエン

To investigate the relationship among stationary monitoring and personal monitoring in workplaces using solvent mixture (survey 1) and single toluene (survey 2), three sets of air samples were taken. A first set of samples (WP) was taken at many points equally distributed in the workplace to get an average value by A sampling. A second set (PW) was obtained from places proximity of the workers, a third set (BZ) was secured from the breathing zone of the workers. In both surveys, close correlation were found among the concentrations for each air sampling, i.e. there was a close relationship when comparing (PW) to (BZ) and (WP) to (BZ). In survey 2, there was also a close relationship of the concentration of toluene in the air of (BZ) or (WP) with the concentration of toluene and hippuric acid in the urine of the workers. The results suggest that the concentration of solvents in the places proximity of workers is a useful indicator of the amount of exposure to workers who remained same place most of their working time.

为了研究工作场所中使用溶剂混合物（调查 1）和单一甲苯（调查 2）的固定监测和个人监测之间的关系，采集了三组空气样本。第一组样本 (WP) 在工作场所的许多点均匀分布，通过 A 抽样获得平均值。第二组（PW）是从工人附近的地方获得的，第三组（BZ）是从工人的呼吸区固定的。在两次调查中，每个空气采样的浓度之间都发现了密切的相关性，即比较（PW）与（BZ）以及（WP）与（BZ）时存在密切关系。调查2中，（BZ）或（WP）空气中的甲苯浓度与工人尿液中的甲苯和马尿酸浓度也有密切关系。结果表明，工人附近的溶剂浓度是衡量大部分工作时间留在同一地点的工人接触溶剂量的有用指标。

项目成果

Masana Ogata: "Large scale biological monitoring in Japan" Science of the Total Environment. (in press). (1997)

Masana Ogata：“日本大规模生物监测”总体环境科学。

Masana Ogata: "Evaluation of exposure to mixed solvents by analyzing their metabolites and solvebts in urine" Kawasaki J. Med. Welfare. 1(1). 1-15 (1995)

Masana Ogata：“通过分析尿液中的代谢物和溶剂来评估混合溶剂的暴露” Kawasaki J. Med。

Masana Ogata: "Evaluation of exposure to solvents from their urinary excretions in workers coexposed to toluene,xylene and MIBK" Appl.Occup.Eniron.Hygiene. 10(11). 913-920 (1995)

Masana Ogata：“评估同时接触甲苯、二甲苯和 MIBK 的工人尿液排泄物中溶剂的暴露情况”Appl.Occup.Eniron.Hygiene。

Hiromi Michitsuji: "Desorption of Organic Solvents from Activated Charcoal with 2-Hydroxypyridine" Kawasaki J.Med.Welfare. 1(1). 103-110 (1995)

Hiromi Michitsuji：“用 2-羟基吡啶从活性炭中解吸有机溶剂”川崎 J.Med.Welfare。

Hiromi Michitsuji: "Relationship between the ambient concentration of mixed solvents in workplaces and the concentration of solvents in breathing zone of worker" Kawasaki J.Med.Welfare. 2(2). 83-89 (1996)

Hiromi Michitsuji：“工作场所混合溶剂环境浓度与工人呼吸区溶剂浓度之间的关系”川崎 J.Med.Welfare。