权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Biological Monitoring of Industrial Solvents

工业溶剂的生物监测

基本信息

批准号：
60570256
负责人：
OGATA Masana
金额：
$ 1.28万
依托单位：
Okayama University Medical School
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1985
资助国家：
日本
起止时间：
1985 至 1986
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60570256/
关键词：
biological monitoring biological exposure indices organic solvent urinary metabolite

项目摘要

Correlation between concentration of organic solvents in the air and concentration of their metabolites in the urine was examined. From above results, regression equation and their confidence intervals were calculated. The urinary metabolites corresponding TLV of organic solvents were estimated from the regression equation as follows; hippuric acid of toluene metabolite was 2.35 g/g creat., m-methylhyppuric acid of m-xylene metabolite was 2.05 g/g creat., total trichlorocompound of trichloroethylene metabolite was 334 mg/g creat., and phenol in phenol conjugates of phenol metabolites was 251 mg/g creat.Concentration of organic solvent which can be discriminated exposure from non exposure, using hippuric acid or phenol conjugates was estimated to be 45 ppm of toluene or 2.4 ppm of phenol, respectively. Human biological exposure indices from Commission of European Communities and Documentation of Biological Exposure Indices(1986-1987) from ACGIH were translated into Japanese. And urinary metabolite concentration corresponding TLV of solvent concentration (benzene and hexane etc.) were estimated from references and validity was discussed. Concentration of urinary metabolites corrected with creatinine was decided to be av ilable for biological monitoring.Total trichlorocompounds in the urine were studied for storage as follows;urine was frozen and kept -20゜C, or urine was spotted onto filterpaper and dried in a cold room, resulting in amounts of trichlorocompound suffered no markedly change for 7-10 days by both methods.

研究了空气中有机溶剂浓度与其尿液中代谢物浓度之间的相关性。根据以上结果，计算回归方程及其置信区间。有机溶剂的尿代谢物相应的TLV由回归方程估计如下；甲苯代谢物的马尿酸为2.35 g/g创造物，间二甲苯代谢物的间甲基次尿酸为2.05 g/g创造物，三氯乙烯代谢物的总三氯化合物为334 mg/g创造物，苯酚代谢物的酚缀合物中的苯酚为251 mg/g创造物。可以区分暴露与非暴露，使用马尿酸或苯酚缀合物估计分别为 45 ppm 甲苯或 2.4 ppm 苯酚。欧洲共同体委员会的人体生物暴露指数和 ACGIH 的生物暴露指数文件（1986-1987）已翻译成日语。并根据参考文献估算了尿代谢物浓度对应的溶剂浓度（苯、己烷等）TLV，并讨论了有效性。经肌酐校正的尿液代谢物浓度确定可用于生物监测。尿液中总三氯化合物的保存研究如下：将尿液冷冻保存-20゜C，或将尿液点在滤纸上并在冷藏室中干燥，结果两种方法7-10天内三氯化合物的量没有明显变化。