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Role of tetrahydroisoquinoline on production of alcohol dependence

四氢异喹啉对酒精依赖产生的作用

基本信息

批准号：
62570264
负责人：
ADACHI Junko
金额：
$ 1.28万
依托单位：
Kobe University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1987
资助国家：
日本
起止时间：
1987 至 1988
项目状态：
已结题

项目摘要

Urinary excretion of tetrahydroisoquinoline in 30 male alcoholic patients during the withdrawal period was determined. They were divided into two groups, i.e., Group A with 14 subjects had a high level of urinary tetrahydroisoquinoline (51.9 40.8 ng/mg creatinine) on admission to a hospital, and group B with 16 subjects showed a low level of the substance (3.9 1.9 ng/mg creatinine). Following a sustained drinking bout, urinary tetrahydroisoquinoline in Group A declined to a normal level within a few days. We found that the subjects in Group A showed a greater excretion of urinary dopamine and norepinephrine than those in Group B. There were no differences between the two groups in levels of blood ethanol, serum GOT, GPT and r-GTP.Healthy Japanese male volunteers were divided into two groups, i.e., a normal aldehyde dehydrogenase (ALDH) group of 13 subjects with a low Km isozyme of ALDH and a deficient group of 12 subjects. The subjects were given 0.4 or 0.8 g/kg of ethanol. Blood ethanol and acetaldehyde levels, urinary excretion of tetrahydroisoquinoline were determined. A sigificant elevation of thtrahydroisoquinoline in urine was found after intake of 0,8 g/kg of ethanol in the two groups, but the increase in the deficient group was greater than that in the normal group, while 0.4 g/kg of ethanol did not affect the excretion of terahydroisoquinoline in either group. Blood acetaldehyde was highly correlated with urinary tetrahydroisoquinoline (r=0.88, p<0.001) and the correlation coefficient was greater than that between blood ethanol and tetrahydroisoquinoline.

本文测定了30例男性酒精中毒患者戒断期尿四氢异喹啉排泄量。他们被分为两组，即，A组有14名受试者有一个高水平的尿四氢异喹啉（51.9 - 40.8纳克/毫克肌酐）入院时，和组B与16名受试者表现出低水平的物质（3.9 - 1.9纳克/毫克肌酐）。在持续饮酒后，A组的尿四氢异喹啉在几天内下降到正常水平。我们发现A组受试者尿多巴胺和去甲肾上腺素的排泄量大于B组。两组间血乙醇、血清GOT、GPT和r-GTP水平无差异。健康日本男性志愿者分为两组，醛脱氢酶（ALDH）正常组13例，ALDH Km同工酶低，缺陷组12例。受试者被给予0.4或0.8 g/kg的乙醇。测定血乙醇和乙醛水平，尿四氢异喹啉排泄量。两组大鼠摄入0.8g/kg乙醇后尿中四氢异喹啉均显著升高，但缺乏组的升高幅度大于正常组，而0.4g/kg乙醇对两组大鼠尿中四氢异喹啉的排泄无影响。血乙醛与尿四氢异喹啉高度相关（r=0.88，p<0.001），相关系数大于血乙醇与四氢异喹啉的相关系数。