Membrane Proteins within the Mouse Transcriptome- Annotation of their Organisation and Subcellular Localisation

小鼠转录组中的膜蛋白 - 其组织和亚细胞定位的注释

• 批准号: DP0450790
• 负责人: A/Prof Rohan Teasdale
• 金额: $ 15.67万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0450790
• 关键词: Membrane; Proteins; within; Mouse; Transcriptome

A major issue in cell biology today is how distinct regions of the cell maintain their unique composition of proteins. The aim of this grant is to identify membrane proteins within the mouse genome and annotate their localisation within the cell. Our multi-discipline effort will combine extensive computational prediction strategies with focused cellular biology experimental determination. The underpinning experimental technology, termed reverse transfection arrays, allows for high-throughput assessment of cellular phenotype properties for individual proteins.

今天细胞生物学中的一个主要问题是细胞的不同区域如何保持其独特的蛋白质组成。这项资助的目的是识别小鼠基因组中的膜蛋白，并注释它们在细胞内的定位。我们的多学科努力将结合广泛的计算预测策略和专注的细胞生物学实验确定。基础实验技术，称为反向转染阵列，允许高通量评估单个蛋白质的细胞表型属性。