Alternative Splicing in the Mouse Transcriptome

小鼠转录组中的选择性剪接

• 批准号: DP0346749
• 负责人: A/Prof Rohan Teasdale
• 金额: $ 6.83万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0346749
• 关键词: Alternative; Splicing; Mouse; Transcriptome

Although the human genome completion is cause for excitement we do not have any firm indication of precisely how many protein-coding genes exist in a mammalian genome. We have even less indication of the extent to which these genes generate alternative gene products, through a process termed alternative splicing. The detection and sequencing of these full-length alternative gene products is the focus of this application. This application details the opportunity to participate in the identification of the full transcriptome of the mouse and is part of a collaborative effort with The RIKEN Genome Sciences Center in Japan.

虽然人类基因组的完成令人兴奋，但我们没有任何确切的迹象表明哺乳动物基因组中存在多少蛋白质编码基因。对于这些基因通过可变剪接产生可变基因产物的程度，我们甚至没有什么证据。这些全长替代基因产物的检测和测序是该应用的重点。该申请详细介绍了参与小鼠全转录组鉴定的机会，是与日本RIKEN基因组科学中心合作的一部分。