Formation of the Chlamydial Inclusion Requires Host Trafficking Pathways

衣原体包涵体的形成需要宿主贩运途径

• 批准号: DP150100364
• 负责人: A/Prof Rohan Teasdale
• 金额: $ 25.55万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150100364
• 关键词: Formation; Chlamydial; Inclusion; Requires; Host

Using cellular and biochemical approaches this project aims to examine the membrane trafficking pathways hijacked by the pathogen Chlamydia and to define the key components of these pathways. Chlamydia are obligate intracellular pathogens responsible for a range of human and animal diseases. In order to survive within the host cell, the pathogen hijacks the host's membrane trafficking pathways to engineer an intracellular niche called an inclusion. In addition to providing a permissive environment, this strategy also shields the pathogen from the host's immune system.

利用细胞和生物化学的方法，该项目的目的是检查被病原体衣原体劫持的膜运输途径，并确定这些途径的关键组成部分。衣原体是导致一系列人类和动物疾病的专性细胞内病原体。为了在宿主细胞内存活，病原体劫持宿主的膜运输途径以工程化称为内含物的细胞内小生境。除了提供一个允许的环境，这种策略还可以保护病原体免受宿主免疫系统的影响。