The molecular basis of macropinocytosis in mammalian cells: the composition of endosome proteins and their function

哺乳动物细胞巨胞饮作用的分子基础：内体蛋白的组成及其功能

• 批准号: DP0771706
• 负责人: A/Prof Rohan Teasdale
• 金额: $ 18.25万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0771706
• 关键词: molecular; basis; macropinocytosis; mammalian; cells

Individual cells communicate with their immediate environment by the process of macropinocytosis, a process that involves the exchange of materials between the extracellular space and a specialised region of the cell termed endosomes. It is an important process in mammalian cells being essential to the correct functioning of many tissues. This project will advance understanding of macropinocytosis at a molecular level. The project is relevant to understanding the functioning of normal cells and the means by which some pathogens can enter cells and also understanding processes involved in tumour progression and metastasis.

单个细胞通过巨胞饮过程与其直接环境进行交流，这一过程涉及细胞外空间和称为内体的细胞专门区域之间的物质交换。这是哺乳动物细胞中的一个重要过程，对许多组织的正确功能至关重要。这个项目将在分子水平上推进对巨胞饮作用的理解。该项目与了解正常细胞的功能以及某些病原体进入细胞的方式有关，也与了解肿瘤进展和转移的过程有关。